5-methyl-3-iminoisoindolin-1-one

Base Information

• Chemical Name: 5-methyl-3-iminoisoindolin-1-one
• CAS No.: 1015228-02-0
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Mol file: 1015228-02-0.mol

Synonyms:

Chemical Property of 5-methyl-3-iminoisoindolin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-3-iminoisoindolin-1-one

There total 2 articles about 5-methyl-3-iminoisoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylphthalonitrile (63089-50-9) → 5-methyl-3-iminoisoindolin-1-one (1015228-02-0) + 6-methyl-3-iminoisoindolin-1-one (127511-07-3)

Guidance literature:

With N-ethyl-N-hydroxy-ethanamine; In chloroform; for 4h; Reflux;

DOI:10.1002/adsc.200700261

Reference yield:

N-ethyl-N-hydroxy-ethanamine (3710-84-7) + 4-methylphthalonitrile (63089-50-9) → 3-aza-2-pentene (1190-79-0) + 5-methyl-3-iminoisoindolin-1-one (1015228-02-0) + 6-methyl-3-iminoisoindolin-1-one (127511-07-3)

Guidance literature:

In chloroform;

DOI:10.1002/adsc.200700261

Reference yield:

5-methyl-3-iminoisoindolin-1-one (1015228-02-0) + nickel(II) acetate tetrahydrate (6018-89-9) + phenylacetonitrile (140-29-4) + 6-methyl-3-iminoisoindolin-1-one (127511-07-3) → (Ni(NHC(CCl3)NC(CCl3)NH)2) (26259-22-3) + [Ni(NH=C(CH2Ph)N=C(C6H3(Me)CON))2] (1015227-93-6) + [Ni(NH=C(CH2Ph)N=C(C6H3(Me)CON))2] (1015228-01-9)

Guidance literature:

With triethanolamine; In further solvent(s); Ni(OAc)2*4H2O and PhCH2CN were heated at 100°C for 15 min, triethanolamine was added and heated at 100°C for 20 min, 3-iminoisoindolin-1-one was added and heated at 100°C for 5 h; ppt. was filtered, washed with acetone and Et2O and dried in air at 20-25°C - isomers were not separated; elem. anal.;

DOI:10.1021/ic702131k

upstream raw materials:

N-ethyl-N-hydroxy-ethanamine

4-methylphthalonitrile

Downstream raw materials:

(Ni(NHC(CCl₃)NC(CCl₃)NH)2)

[Ni(NH=C(CH₂Ph)N=C(C₆H₃(Me)CON))2]

[Ni(NH=C(CH₂Ph)N=C(C₆H₃(Me)CON))2]