1,1'-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-Methyl-piperazine

Base Information

• Chemical Name: 1,1'-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-Methyl-piperazine
• CAS No.: 519138-47-7
• Molecular Formula: C₂₄H₃₀Cl₄N₄
• Molecular Weight: 516.341
• Mol file: 519138-47-7.mol

Synonyms:

Chemical Property of 1,1'-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-Methyl-piperazine

Chemical Property:

• Boiling Point: 616.4±55.0 °C(Predicted)
• PKA: 7.74±0.42(Predicted)
• Density: 1.289±0.06 g/cm3(Predicted)
• Solubility.: Chloroform, Dichloromethane

Purity/Quality:

1,1''-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-methyl-piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1,1'-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-methyl-piperazine is an intermediate in the preparation of ethylidenebisaripiprazole. 1,1''-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-methyl-piperazine is an intermediate in the preparation of ethylidenebisaripiprazole.

Technology Process of 1,1'-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-Methyl-piperazine

There total 1 articles about 1,1'-[Ethylidenebis(2,3-dichloro-4,1-phenylene)]bis[4-Methyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + C16H14Cl4O2 (397301-41-6) → C24H30Cl4N4 (519138-47-7)

Guidance literature:

With n-butyllithium; In 1,2-dimethoxyethane; hexane; at 25 - 30 ℃; for 3h;

DOI:10.1016/S0960-894X(02)00857-0

Reference yield:

carbonochloridic acid 1-chloro-ethyl ester (50893-53-3) + C24H30Cl4N4 (519138-47-7) → C28H32Cl6N4O4

Guidance literature:

In 1,2-dichloro-ethane; at 50 - 60 ℃; for 5h;

DOI:10.1016/S0960-894X(02)00857-0

Reference yield:

C24H30Cl4N4 (519138-47-7) → C22H26Cl4N4*2ClH

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 5 h / 50 - 60 °C

2: methanol; 1,2-dichloro-ethane / Heating

In methanol; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(02)00857-0

upstream raw materials:

1-methyl-piperazine

C₁₆H₁₄Cl₄O₂

Refernces