C₁₈H₁₅F₃N₂O₃

Base Information

• Chemical Name: C₁₈H₁₅F₃N₂O₃
• CAS No.: 1357104-48-3
• Molecular Formula: C₁₈H₁₅F₃N₂O₃
• Molecular Weight: 364.324
• Mol file: 1357104-48-3.mol

Synonyms:

Chemical Property of C₁₈H₁₅F₃N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₅F₃N₂O₃

There total 3 articles about C₁₈H₁₅F₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-[(4-methoxyphenyl)methyl]isoindolin-1-one + 2,2,2-trifluoroacetamide (354-38-1) → C18H15F3N2O3 (1357104-48-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 80 ℃; for 12h;

DOI:10.1016/j.bmcl.2011.12.063

Reference yield:

benzyl chloride (100-44-7) → C18H15F3N2O3 (1357104-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 6 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 12 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.12.063

Reference yield:

5-bromoisoindolin-1-one (552330-86-6) → C18H15F3N2O3 (1357104-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 6 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 12 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.12.063

upstream raw materials:

2,2,2-trifluoroacetamide

5-bromoisoindolin-1-one

benzyl chloride

Downstream raw materials:

5-amino-2,3-dihydro-1H-benzo[c]azol-1-one

C₁₀H₇F₃N₂O₂