Technology Process of (2S,4S)-1-(2,5-dimethoxyphenyl)-1,2,4,5-tetrahydroxy-3-deoxy-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentitol
There total 6 articles about (2S,4S)-1-(2,5-dimethoxyphenyl)-1,2,4,5-tetrahydroxy-3-deoxy-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / LiAlH4 / diethyl ether / Heating
2: 93.5 percent / pyridinium dichromate, molecular sieves powder, CH3COOH / CH2Cl2 / 1 h / Ambient temperature
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 1 h
With
lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; molecular sieve; acetic acid;
In
diethyl ether; dichloromethane;
DOI:10.1021/jo00382a016
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 93.5 percent / pyridinium dichromate, molecular sieves powder, CH3COOH / CH2Cl2 / 1 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 1 h
With
dipyridinium dichromate; n-butyllithium; molecular sieve; acetic acid;
In
dichloromethane;
DOI:10.1021/jo00382a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / Amberlyst 15 / methanol / 75 h / Ambient temperature
2: 97 percent / LiAlH4 / diethyl ether / Heating
3: 93.5 percent / pyridinium dichromate, molecular sieves powder, CH3COOH / CH2Cl2 / 1 h / Ambient temperature
4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 1 h
With
lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; Amberlyst 15; molecular sieve; acetic acid;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00382a016
