tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate
• CAS No.: 1240298-42-3
• Molecular Formula: C₃₆H₃₆FN₅O₇
• Molecular Weight: 669.71
• Mol file: 1240298-42-3.mol

Synonyms:

Chemical Property of tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide (925922-99-2) + (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine (56502-01-3) → tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate (1240298-42-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 120h;

DOI:10.1016/j.bmc.2010.05.061

Reference yield:

tert-butyl (2S)-2-{2-[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)amino]-2-oxoethyl}pyrrolidine-1-carboxylate (1240298-42-3) → N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-(3-{[(2S)-pyrrolidin-2-ylacetyl]amino}phenyl)pyridin-2-yl]furan-2-carboxamide hydrochloride (925929-34-6)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmc.2010.05.061

upstream raw materials:

N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide

(2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine

Downstream raw materials:

N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-(3-{[(2S)-pyrrolidin-2-ylacetyl]amino}phenyl)pyridin-2-yl]furan-2-carboxamide hydrochloride