(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid

Base Information

• Chemical Name: (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid
• CAS No.: 253687-67-1
• Molecular Formula: C₃₇H₅₈BrN₁₁O₈
• Molecular Weight: 864.84
• Mol file: 253687-67-1.mol

Synonyms:

Chemical Property of (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid

There total 1 articles about (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-azido-5-bromovaleric acid (203739-39-3) → (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid (253687-67-1)

Guidance literature:

(2S)-2-azido-5-bromovaleric acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

Wang-resin bound side-chain protected NH₂-Arg-Pro-Tyr-Ile-Leu;

With trifluoroacetic acid; for 3h;

DOI:10.1021/jm9903444

Reference yield:

(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid (253687-67-1) → (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-5-Amino-2-azido-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid

Guidance literature:

With ammonium hydroxide; In ethanol;

DOI:10.1021/jm9903444

Reference yield:

dimethyl amine (124-40-3) + (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-bromo-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid (253687-67-1) → (S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Azido-5-dimethylamino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid

Guidance literature:

In ethanol; water;

DOI:10.1021/jm9903444

upstream raw materials:

(2S)-2-azido-5-bromovaleric acid