Technology Process of 3-Quinolinecarboxylic acid,
1-(2,4-difluorophenyl)-7-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-fluoro-1,4
-dihydro-4-oxo-, ethyl ester
There total 5 articles about 3-Quinolinecarboxylic acid,
1-(2,4-difluorophenyl)-7-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-fluoro-1,4
-dihydro-4-oxo-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
at 60 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C
2: 99 percent / H2 / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature
3: 65 percent / pyridine / 48 h / 60 °C
With
pyridine; hydrogen; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
methanol; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1 M aq. NaOH / diethyl ether / 3 h
2: 91 percent / pyridine-SO3, Et3N / dimethylsulfoxide / 1 h / 0 °C
3: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C
4: 99 percent / H2 / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature
5: 65 percent / pyridine / 48 h / 60 °C
With
pyridine; sodium hydroxide; hydrogen; sulfur trioxide pyridine complex; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
methanol; diethyl ether; dimethyl sulfoxide; ethyl acetate; toluene;
