(2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane

Base Information

• Chemical Name: (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane
• CAS No.: 1026335-14-7
• Molecular Formula: C₂₅H₄₈O₄Si₂
• Molecular Weight: 468.825
• Mol file: 1026335-14-7.mol

Synonyms:

Chemical Property of (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane

There total 3 articles about (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<2-methyl-5-<(tert-butyldimethylsilyl)oxy>-1-cyclopentenyl>methanol (145315-18-0) → (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane (1026335-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TEA, MsCl; 2.) DMAP / 1.) CH₂Cl₂, 0 deg C, 1 h; 2.) CH₂Cl₂, 0 deg C, 1 h then r.t., 16 h

2: LDA, TEA / tetrahydrofuran / -110 deg C, 10 min then up to 0 deg C

With dmap; TEA; methanesulfonyl chloride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)80841-3

Reference yield:

(1R,2S,4S)-2-Methoxy-4-methyl-cyclohexanecarboxylic acid → (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane (1026335-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TEA, MsCl; 2.) DMAP / 1.) CH₂Cl₂, 0 deg C, 1 h; 2.) CH₂Cl₂, 0 deg C, 1 h then r.t., 16 h

2: LDA, TEA / tetrahydrofuran / -110 deg C, 10 min then up to 0 deg C

With dmap; TEA; methanesulfonyl chloride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)80841-3

Reference yield:

chloro-trimethyl-silane (75-77-4) + <1-<(tert-butyldimethylsilyl)oxy>(3-methyl-2-cyclopentenyl)-2-methyl> (1R,2S,4S)-2-methoxy-4-methylcyclohexanecarboxylate → (2S,4S)-1-[1-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-methoxy-4-methyl-cyclohexane (1026335-14-7)

Guidance literature:

With TEA; lithium diisopropyl amide; In tetrahydrofuran; -110 deg C, 10 min then up to 0 deg C;

DOI:10.1016/S0040-4020(01)80841-3

upstream raw materials:

chloro-trimethyl-silane

<2-methyl-5-<(tert-butyldimethylsilyl)oxy>-1-cyclopentenyl>methanol