(E)-N⁴-(4-chlorophenyl)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide

Base Information

• Chemical Name: (E)-N⁴-(4-chlorophenyl)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide
• CAS No.: 1428787-99-8
• Molecular Formula: C₃₂H₃₄ClFN₆O₄
• Molecular Weight: 621.111
• Mol file: 1428787-99-8.mol

Synonyms:

Chemical Property of (E)-N⁴-(4-chlorophenyl)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N⁴-(4-chlorophenyl)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide

There total 11 articles about (E)-N⁴-(4-chlorophenyl)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.9%

p-chlorophenylsemicarbazide (69194-89-4) + 3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yl)oxy)benzaldehyde → (E)-N4-(4-chlorophenyl)-N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide (1428787-99-8)

Guidance literature:

With acetic acid; In isopropyl alcohol; Reflux;

DOI:10.1002/ardp.201300087

Reference yield:

phenyl N-(4-chlorophenyl)carbamate (50882-28-5) → (E)-N4-(4-chlorophenyl)-N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide (1428787-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / water; 1,4-dioxane / Reflux

2: acetic acid / isopropyl alcohol / Reflux

With hydrazine hydrate; acetic acid; In 1,4-dioxane; water; isopropyl alcohol;

DOI:10.1002/ardp.201300087

Reference yield:

6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline (1394166-09-6,1428788-16-2) → (E)-N4-(4-chlorophenyl)-N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide (1428787-99-8)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 8 h / 25 - 85 °C

2: trichlorophosphate / acetonitrile / 6 h / Reflux

3: chlorobenzene / 17 h / Reflux

4: acetic acid / isopropyl alcohol / Reflux

With acetic acid; trichlorophosphate; In chlorobenzene; isopropyl alcohol; acetonitrile;

DOI:10.1002/ardp.201300087

upstream raw materials:

phenyl N-(4-chlorophenyl)carbamate

6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline

4-chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)-propoxy)quinoline

1-(3-methoxy-4-hydroxyphenyl)ethanone