2-(Methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Base Information

Chemical Name:2-(Methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine
CAS No.:2627-53-4
Molecular Formula:C10H7 F3 N2 S2
Molecular Weight:276.3012
Hs Code.:
NSC Number:165423
DSSTox Substance ID:DTXSID90304327
Wikidata:Q82050172
Mol file:2627-53-4.mol

Synonyms:2-(methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine;2627-53-4;NSC165423;ST50808086;SCHEMBL19805734;DTXSID90304327;JDPMXQFVFSMNLV-UHFFFAOYSA-N;CAA62753;STK398616;AKOS002283909;NSC-165423;SB59650;NCGC00340257-01;CS-0333416;AB01332114-02;F3358-0311;2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Suppliers and Price of 2-(Methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2-(Methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Chemical Property:

Vapor Pressure:3.24E-05mmHg at 25°C
Boiling Point:365.7°C at 760 mmHg
Flash Point:175°C
Density:1.46g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:276.00027507
Heavy Atom Count:17
Complexity:262

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=NC(=CC(=N1)C(F)(F)F)C2=CC=CS2

Technology Process of 2-(Methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

There total 6 articles about 2-(Methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 398996-45-7
6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2-(1H)-thione

: 74-88-4
methyl iodide

: 2627-53-4
2-(methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Guidance literature:: 6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2-(1H)-thione; With sodium hydride; In tetrahydrofuran; at -20 - 25 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201002850

Reference yield: 61.0%

: 398996-45-7
6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2(1H)-thione

: 74-88-4
methyl iodide

: 2627-53-4
2-(methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Guidance literature:: 6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2(1H)-thione; With sodium hydride; In tetrahydrofuran; at -20 - 25 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo1001615

Reference yield:

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 2627-53-4
2-(methylthio)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 8 h / 95 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / -20 - 25 °C / Inert atmosphere

2.2: 1 h / 25 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; In tetrahydrofuran; ethanol; water;
DOI:10.1002/chem.201002850