dibenzyl n-butyryloxy(phenyl)methane phosphonate

Base Information

• Chemical Name: dibenzyl n-butyryloxy(phenyl)methane phosphonate
• CAS No.: 1378314-01-2
• Molecular Formula: C₂₅H₂₇O₅P
• Molecular Weight: 438.46
• Mol file: 1378314-01-2.mol

Synonyms:

Chemical Property of dibenzyl n-butyryloxy(phenyl)methane phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl n-butyryloxy(phenyl)methane phosphonate

There total 4 articles about dibenzyl n-butyryloxy(phenyl)methane phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378313-91-7) → (S)-dibenzyl [hydroxy(phenyl)methyl]phosphonate + dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378314-01-2) + dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378314-03-4) + (R)-(+)-dibenzyl hydroxy(phenyl)methanephosphonate (119552-91-9,119617-56-0)

Guidance literature:

With lipase from Candida cylindracea; In hexane; di-isopropyl ether; at 20 ℃; for 12h; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.3109/10242422.2011.631211

Reference yield:

dibenzyl hydrogen phosphite (538-60-3) → (S)-dibenzyl [hydroxy(phenyl)methyl]phosphonate + dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378314-01-2) + dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378314-03-4) + (R)-(+)-dibenzyl hydroxy(phenyl)methanephosphonate (119552-91-9,119617-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum oxide; potassium fluoride / 12 h / 20 °C

2: lipase from Candida antarctica A-CLEA / di-isopropyl ether / 168 h / 36 °C / Molecular sieve; Enzymatic reaction

With aluminum oxide; potassium fluoride; lipase from Candida antarctica A-CLEA; In di-isopropyl ether;

DOI:10.3109/10242422.2011.631211

Reference yield:

benzaldehyde (100-52-7) → (S)-dibenzyl [hydroxy(phenyl)methyl]phosphonate + dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378314-01-2) + dibenzyl n-butyryloxy(phenyl)methane phosphonate (1378314-03-4) + (R)-(+)-dibenzyl hydroxy(phenyl)methanephosphonate (119552-91-9,119617-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum oxide; potassium fluoride / 12 h / 20 °C

2: lipase from Candida antarctica A-CLEA / di-isopropyl ether / 168 h / 36 °C / Molecular sieve; Enzymatic reaction

With aluminum oxide; potassium fluoride; lipase from Candida antarctica A-CLEA; In di-isopropyl ether;

DOI:10.3109/10242422.2011.631211

upstream raw materials:

dibenzyl n-butyryloxy(phenyl)methane phosphonate

dibenzyl hydrogen phosphite

benzaldehyde

(+/-)-dibenzyl [hydroxy(phenyl)methyl]phosphonate