C₂₉H₅₃NO₅

Base Information

• Chemical Name: C₂₉H₅₃NO₅
• CAS No.: 1620409-12-2
• Molecular Formula: C₂₉H₅₃NO₅
• Molecular Weight: 495.744
• Mol file: 1620409-12-2.mol

Synonyms:

Chemical Property of C₂₉H₅₃NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₅₃NO₅

There total 14 articles about C₂₉H₅₃NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

carbon monoxide (201230-82-2) + (R)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl formyl-L-leucinate (1620408-88-9) → C29H53NO5 (1620409-12-2) + (R)-1'-<((2''S,3''S)-3''-hexyl-4''-oxo-2''-oxetanyl)methyl>dodecyl (S)-N-formylleucinate (1225451-00-2)

Guidance literature:

With bis(tetrahydrofuran)-meso-tetra(4-chlorophenyl)porphyrinato aluminum tetracarbonyl cobaltate; In tetrahydrofuran; at -30 - 50 ℃; for 24h; under 46544.6 Torr; Glovebox; Autoclave;

DOI:10.1021/acsmedchemlett.8b00050

Reference yield:

N-formyl-L-leucine (5338-45-4,44978-39-4,89921-44-8,6113-61-7) → C29H53NO5 (1620409-12-2) + (R)-1'-<((2''S,3''S)-3''-hexyl-4''-oxo-2''-oxetanyl)methyl>dodecyl (S)-N-formylleucinate (1225451-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere

2: bis(tetrahydrofuran)-meso-tetra(4-chlorophenyl)porphyrinato aluminum tetracarbonyl cobaltate / tetrahydrofuran / 24 h / -30 - 50 °C / 46544.6 Torr / Autoclave; Inert atmosphere

With di-isopropyl azodicarboxylate; bis(tetrahydrofuran)-meso-tetra(4-chlorophenyl)porphyrinato aluminum tetracarbonyl cobaltate; triphenylphosphine; In tetrahydrofuran; 1: |Mitsunobu Displacement;

DOI:10.1021/ja505639u

Reference yield:

N-methoxy-N-methyl dodecanamide (943346-53-0) → C29H53NO5 (1620409-12-2) + (R)-1'-<((2''S,3''S)-3''-hexyl-4''-oxo-2''-oxetanyl)methyl>dodecyl (S)-N-formylleucinate (1225451-00-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: tetrahydrofuran / 0.5 h / -15 °C / Inert atmosphere

2.1: chloro([(S,2S)-(?)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido)(mesitylene)ruthenium (II); triethylamine; formic acid / 12 h / 20 °C / Inert atmosphere

3.1: potassium hydride; Trimethylenediamine / 18 h / 15 - 20 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

5.1: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

5.2: 12 h / -20 - 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

7.1: quinoline; 5% Pd-CaCO3; hydrogen / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

8.1: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane; decane / 23 h / 0 - 20 °C / Inert atmosphere

9.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere

10.1: bis(tetrahydrofuran)-meso-tetra(4-chlorophenyl)porphyrinato aluminum tetracarbonyl cobaltate / tetrahydrofuran / 24 h / -30 - 50 °C / 46544.6 Torr / Autoclave; Inert atmosphere

With 1H-imidazole; quinoline; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; chloro([(S,2S)-(?)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido)(mesitylene)ruthenium (II); n-butyllithium; formic acid; bis(acetylacetonate)oxovanadium; di-isopropyl azodicarboxylate; 5% Pd-CaCO3; bis(tetrahydrofuran)-meso-tetra(4-chlorophenyl)porphyrinato aluminum tetracarbonyl cobaltate; tetrabutyl ammonium fluoride; hydrogen; potassium hydride; Trimethylenediamine; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; decane; dichloromethane; N,N-dimethyl-formamide; 9.1: |Mitsunobu Displacement;

DOI:10.1021/ja505639u

upstream raw materials:

N-formyl-L-leucine

carbon monoxide

(R)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl formyl-L-leucinate

N-methoxy-N-methyl dodecanamide