(RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole

Base Information

• Chemical Name: (RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole
• CAS No.: 133534-36-8
• Molecular Formula: C₂₀H₂₂N₂O₃
• Molecular Weight: 338.406
• Mol file: 133534-36-8.mol

Synonyms:

Chemical Property of (RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole

There total 16 articles about (RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Ethoxyphenol (94-71-3) → (RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole (133534-36-8,133534-37-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 57.2 percent / 85percent aq. KOH / 7 h / 70 °C

2: 100 percent / 98percent H₂SO₄ / 40 h / Ambient temperature

3: 100 percent / NaH / dimethylformamide / 1 h / 10 °C

4: 77.4 percent / 30percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

5: 87.6 percent / pyridine, trifluoroacetic anhydride / dioxane / 3 h / Ambient temperature

6: 76.4 percent / HCl (gas) / diethyl ether / 7 h / Ambient temperature

7: 2.) 4 N HCl / 1.) ethanol, RT, 4 h, 2.) RT, 24 h

With pyridine; hydrogenchloride; potassium hydroxide; ammonium hydroxide; sulfuric acid; sodium hydride; trifluoroacetic anhydride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(90)90195-9

Reference yield:

2-Ethoxyphenol (94-71-3) → (RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole (133534-36-8,133534-37-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 77.1 percent / 85percent aq. KOH / 7 h / 70 °C

2: 87 percent / 98percent H₂SO₄ / 40 h / Ambient temperature

3: 88.4 percent / NaH / dimethylformamide / 1 h / 10 °C

4: 82.2 percent / 30percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

5: 100 percent / pyridine, trifluoroacetic anhydride / dioxane / 3 h / Ambient temperature

6: 81.4 percent / HCl (gas) / diethyl ether / 7 h / Ambient temperature

7: 2.) 4 N HCl / 1.) ethanol, RT, 4 h, 2.) RT, 24 h

With pyridine; hydrogenchloride; potassium hydroxide; ammonium hydroxide; sulfuric acid; sodium hydride; trifluoroacetic anhydride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(90)90195-9

Reference yield:

(RS,RS) 2-methoxy-3-(2-ethoxyphenoxy)-benzenepropanenitrile (133534-63-1,133534-66-4) → (RS,RS) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole (133534-36-8,133534-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.4 percent / HCl (gas) / diethyl ether / 7 h / Ambient temperature

2: 2.) 4 N HCl / 1.) ethanol, RT, 4 h, 2.) RT, 24 h

With hydrogenchloride; In diethyl ether;

DOI:10.1016/0223-5234(90)90195-9

upstream raw materials:

(RS,RS) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride

2,2-dimethoxyethylamine

2-Ethoxyphenol

(RS,RS) 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanoic acid

Downstream raw materials:

(RS,SR) 1-ethyl-2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole

(RS,RS) 1-ethyl-2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-1H-imidazole