(5-Amino-1,2-dihydro-3-(((4-methoxyphenyl)methylamino)methyl)pyrido (- 3,4-b)pyrazin-7-yl)-, carbamic acid, ethyl ester

Base Information

• Chemical Name: (5-Amino-1,2-dihydro-3-(((4-methoxyphenyl)methylamino)methyl)pyrido (- 3,4-b)pyrazin-7-yl)-, carbamic acid, ethyl ester
• CAS No.: 82585-90-8
• Molecular Formula: C19H24 N6 O3
• Molecular Weight: 384.438
• Mol file: 82585-90-8.mol

Synonyms:Pyrido[3,4-b]pyrazine,carbamic acid deriv.; NSC 269416; SRI 5713

Chemical Property of (5-Amino-1,2-dihydro-3-(((4-methoxyphenyl)methylamino)methyl)pyrido (- 3,4-b)pyrazin-7-yl)-, carbamic acid, ethyl ester

Chemical Property:

• Vapor Pressure: 4.2E-13mmHg at 25°C
• Boiling Point: 572.2°C at 760 mmHg
• Flash Point: 299.9°C
• PSA: 114.10000
• Density: 1.34g/cm³
• LogP: 3.10300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-Amino-1,2-dihydro-3-(((4-methoxyphenyl)methylamino)methyl)pyrido (- 3,4-b)pyrazin-7-yl)-, carbamic acid, ethyl ester

There total 5 articles about (5-Amino-1,2-dihydro-3-(((4-methoxyphenyl)methylamino)methyl)pyrido (- 3,4-b)pyrazin-7-yl)-, carbamic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(6-Amino-4-{2-[(E)-hydroxyimino]-3-[(4-methoxy-phenyl)-methyl-amino]-propylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester (82585-58-8) → (5-amino-3-[(4-methoxy-phenyl)-methyl-amino]-methyl-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl)-carbamic acid ethyl ester (82585-90-8)

Guidance literature:

With hydrogen; nickel; In ethanol; for 3h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00351a008

Reference yield:

1-Amino-3-[(4-methoxy-phenyl)-methyl-amino]-propan-2-one oxime (82740-35-0) → (5-amino-3-[(4-methoxy-phenyl)-methyl-amino]-methyl-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl)-carbamic acid ethyl ester (82585-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N / methanol / 15 h / 75 °C

2: 73 percent / H₂ / Raney nickel / ethanol / 3 h / 760 Torr / Ambient temperature

With hydrogen; triethylamine; nickel; In methanol; ethanol;

DOI:10.1021/jm00351a008

Reference yield:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) → (5-amino-3-[(4-methoxy-phenyl)-methyl-amino]-methyl-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl)-carbamic acid ethyl ester (82585-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N / methanol / 15 h / 75 °C

2: 73 percent / H₂ / Raney nickel / ethanol / 3 h / 760 Torr / Ambient temperature

With hydrogen; triethylamine; nickel; In methanol; ethanol;

DOI:10.1021/jm00351a008

upstream raw materials:

(6-Amino-4-{2-[(E)-hydroxyimino]-3-[(4-methoxy-phenyl)-methyl-amino]-propylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

1-Amino-3-[(4-methoxy-phenyl)-methyl-amino]-propan-2-one oxime

2-{2-[(E)-Hydroxyimino]-3-[(4-methoxy-phenyl)-methyl-amino]-propyl}-isoindole-1,3-dione