C₁₈H₁₈BrNO₂

Base Information

• Chemical Name: C₁₈H₁₈BrNO₂
• CAS No.: 1569273-00-2
• Molecular Formula: C₁₈H₁₈BrNO₂
• Molecular Weight: 360.25
• Mol file: 1569273-00-2.mol

Synonyms:

Chemical Property of C₁₈H₁₈BrNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₈BrNO₂

There total 4 articles about C₁₈H₁₈BrNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-naphthalene-2-carboxylic acid methyl ester (948-03-8) → C18H18BrNO2 (1569273-00-2)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 1 h / -5 °C

2: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

3: bromine; acetic acid / 19 h / 20 - 90 °C / Inert atmosphere

4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / 90 °C / Inert atmosphere

5: tetrahydrofuran / 15 h

With pyridine; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; bromine; acetic acid; lithium chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; 2: |Stille Cross Coupling;

DOI:10.1021/ml500055h

Reference yield:

1-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoic acid methyl ester → C18H18BrNO2 (1569273-00-2)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

2: bromine; acetic acid / 19 h / 20 - 90 °C / Inert atmosphere

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / 90 °C / Inert atmosphere

4: tetrahydrofuran / 15 h

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; bromine; acetic acid; lithium chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; 1: |Stille Cross Coupling;

DOI:10.1021/ml500055h

Reference yield:

methyl 1-methyl-2-naphthoate (73721-17-2) → C18H18BrNO2 (1569273-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; acetic acid / 19 h / 20 - 90 °C / Inert atmosphere

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / 90 °C / Inert atmosphere

3: tetrahydrofuran / 15 h

With N-Bromosuccinimide; bromine; acetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/ml500055h

upstream raw materials:

(1R,2S)-2-amino-1-cyclohexanol

methyl 4-bromo-1-(bromomethyl)-2-naphthoate

1-hydroxy-naphthalene-2-carboxylic acid methyl ester

methyl 1-methyl-2-naphthoate

Downstream raw materials:

C₁₉H₁₉NO₃

C₃₀H₃₂N₄O₂

C₂₀H₂₁NO₂