MTX-211

Base Information

• Chemical Name: MTX-211
• CAS No.: 1952236-05-3
• Molecular Formula: C₂₀H₁₄Cl₂FN₅O₂S
• Molecular Weight: 478.334
• Mol file: 1952236-05-3.mol

Synonyms:

Chemical Property of MTX-211

Chemical Property:

• Boiling Point: 642.8±65.0 °C(Predicted)
• PKA: 5.61±0.50(Predicted)
• Density: 1.577±0.06 g/cm3(Predicted)

Purity/Quality:

98% min ^*data from raw suppliers

MTX211 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MTX-211

There total 5 articles about MTX-211 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

6-(5-amino-6-chloropyridin-3-yl)-N-(3-chloro-4-fluorophenyl)quinazolin-4-amine + methanesulfonyl chloride (124-63-0) → N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)pyridin-3-yl)methanesulfonamide (1952236-05-3)

Guidance literature:

With pyridine; at 20 ℃;

Reference yield:

6-bromo-4-chloroquinozoline (38267-96-8) → N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)pyridin-3-yl)methanesulfonamide (1952236-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: isopropyl alcohol / 80 °C / Inert atmosphere

2: potassium carbonate / 1,4-dioxane / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: pyridine / 20 °C

With pyridine; potassium carbonate; In 1,4-dioxane; isopropyl alcohol; 2: |Suzuki Coupling;

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) → N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)pyridin-3-yl)methanesulfonamide (1952236-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: isopropyl alcohol / 80 °C / Inert atmosphere

2: potassium carbonate / 1,4-dioxane / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: pyridine / 20 °C

With pyridine; potassium carbonate; In 1,4-dioxane; isopropyl alcohol; 2: |Suzuki Coupling;

upstream raw materials:

methanesulfonyl chloride

6-bromo-4-chloroquinozoline

3-chloro-4-fluorophenylamine

6-bromo-N-(3-chloro-4-fluorophenyl)-4-quinazolinamine