N4,N4,6-trimethylpyrimidine-2,4-diamine

Base Information

• Chemical Name: N4,N4,6-trimethylpyrimidine-2,4-diamine
• CAS No.: 68302-95-4
• Molecular Formula: C₇H₁₂N₄
• Molecular Weight: 152.199
• European Community (EC) Number: 887-325-9
• Nikkaji Number: J3.195.625K
• Wikidata: Q107909765
• Mol file: 68302-95-4.mol

Synonyms:2-amino-4-dimethylamino-6-methylpyrimidine

Chemical Property of N4,N4,6-trimethylpyrimidine-2,4-diamine

Chemical Property:

• Melting Point: 169-170 °C
• Boiling Point: 343.1±34.0 °C(Predicted)
• PKA: 8.14±0.10(Predicted)
• Density: 1.149±0.06 g/cm3(Predicted)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 152.106196400
• Heavy Atom Count: 11
• Complexity: 126

Purity/Quality:

97% ^*data from raw suppliers

4-N,4-N,6-trimethylpyrimidine-2,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N)N(C)C

Technology Process of N4,N4,6-trimethylpyrimidine-2,4-diamine

There total 4 articles about N4,N4,6-trimethylpyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-amino-4-methyl-6-dimethylaminopyrimidine (68302-95-4)

Guidance literature:

With ammonia; In water; at 240 ℃; for 0.5h;

DOI:10.1021/jo400390t

Reference yield:

2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + dimethyl amine (124-40-3) → 2-amino-4-methyl-6-dimethylaminopyrimidine (68302-95-4)

Guidance literature:

With ethanol; at 110 - 120 ℃;

DOI:10.1093/geront/41.2.153

Reference yield:

2-amino-6-methyl-4-chloropyrimidine (5600-21-5) → 2-amino-4-methyl-6-dimethylaminopyrimidine (68302-95-4)

Guidance literature:

In water;

upstream raw materials:

2-amino-6-methyl-4-chloropyrimidine

dimethyl amine

N,N-dimethyl-formamide