(R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester

Base Information

• Chemical Name: (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester
• CAS No.: 1448510-81-3
• Molecular Formula: C₁₇H₂₃NO₇
• Molecular Weight: 353.372
• Mol file: 1448510-81-3.mol

Synonyms:

Chemical Property of (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester

There total 7 articles about (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + chloroformic acid ethyl ester (541-41-3) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester (1448510-81-3) + (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine methyl ester (1448510-82-4)

Guidance literature:

L-tyrosine; With tyrosine aminomutase from Chondromy cescrocatus; In aq. phosphate buffer; at 31 ℃; for 1h; pH=8.5; Enzymatic reaction;

chloroformic acid ethyl ester; With pyridine; In aq. phosphate buffer; for 0.166667h; Enzymatic reaction;

diazomethane; Further stages;

DOI:10.1021/ja403918w

Reference yield:

(2S,3R)-[2,3-2H]-α-tyrosine (34100-65-7) + chloroformic acid ethyl ester (541-41-3) → (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester (1448510-81-3)

Guidance literature:

(2S,3R)-[2,3-²H]-α-tyrosine; With tyrosine aminomutase from Chondromy cescrocatus; In aq. phosphate buffer; at 31 ℃; for 1h; pH=8.5; Enzymatic reaction;

chloroformic acid ethyl ester; With pyridine; In aq. phosphate buffer; for 0.166667h; Further stages; Enzymatic reaction;

DOI:10.1021/ja403918w

Reference yield:

chloroformic acid ethyl ester (541-41-3) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → (R)-4'-O,3-N-di(ethoxycarbonyl)-β-tyrosine ethyl ester (1448510-81-3)

Guidance literature:

L-tyrosine; With tyrosine aminomutase from Chondromy cescrocatus; In aq. phosphate buffer; at 31 ℃; for 1h; pH=8.5; Enzymatic reaction;

chloroformic acid ethyl ester; With pyridine; In aq. phosphate buffer; for 0.166667h; Further stages; Enzymatic reaction;

DOI:10.1021/ja403918w

upstream raw materials:

(2S,3R)-[2,3-²H]-α-tyrosine

chloroformic acid ethyl ester

L-tyrosine

diazomethane