(4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one

Base Information

• Chemical Name: (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one
• CAS No.: 152929-98-1
• Molecular Formula: C₃₁H₄₂N₂O₅
• Molecular Weight: 522.685
• Mol file: 152929-98-1.mol

Synonyms:

Chemical Property of (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one

There total 1 articles about (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxyethoxymethyl chloride (3970-21-6) + XK234 (153223-21-3) → (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one (152929-98-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 8h; Heating;

DOI:10.1021/jo980533e DOI:10.1021/jm9803626

Reference yield:

(4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one (152929-98-1) → (4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one (210635-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.9 g / PPh₃, DEAD / tetrahydrofuran / 20 h / Ambient temperature

2: 0.4 g / 1N aq. NaOH / methanol / 1 h / Ambient temperature

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm9803626

Reference yield:

(4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one (152929-98-1) → (4S,5S,6R)-tetrahydro-1,3-bis--5-hydroxy-4-(1S-hydroxy-2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone

Guidance literature:

Multi-step reaction with 3 steps

1: 0.9 g / PPh₃, DEAD / tetrahydrofuran / 20 h / Ambient temperature

2: 0.4 g / 1N aq. NaOH / methanol / 1 h / Ambient temperature

3: 48 mg / methanolic HCl / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm9803626

upstream raw materials:

2-Methoxyethoxymethyl chloride

XK₂₃₄

Downstream raw materials:

Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester

(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

(4R,5R,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-6-phenethyl-tetrahydro-pyrimidin-2-one

(4R,5S,6S)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-fluoro-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one