Technology Process of Toluene-4-sulfonic acid (S)-3-(3-benzyloxymethoxy-phenyl)-3-methoxy-propyl ester
There total 7 articles about Toluene-4-sulfonic acid (S)-3-(3-benzyloxymethoxy-phenyl)-3-methoxy-propyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 92 percent / diisobutyl aluminum hydride / CH2Cl2; hexane / 1 h / -78 °C
3: 90 percent / (-)-diisopropyl tartrate, titanium tetraisopropoxide, t-butyl hydroperoxide, MS 4 Angstroem / CH2Cl2; toluene / 11 h / -20 °C
4: 91 percent / Red-al / toluene; tetrahydrofuran / 10.2 h / 0 °C
5: 93 percent / triethylamine, 4-DMAP / CH2Cl2 / 4 h / Ambient temperature
6: sodium hydride / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; (-)-diisopropyl tartrate; MS 4 Angstroem; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)81547-7
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 92 percent / diisobutyl aluminum hydride / CH2Cl2; hexane / 1 h / -78 °C
3: 90 percent / (-)-diisopropyl tartrate, titanium tetraisopropoxide, t-butyl hydroperoxide, MS 4 Angstroem / CH2Cl2; toluene / 11 h / -20 °C
4: 91 percent / Red-al / toluene; tetrahydrofuran / 10.2 h / 0 °C
5: 93 percent / triethylamine, 4-DMAP / CH2Cl2 / 4 h / Ambient temperature
6: sodium hydride / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; (-)-diisopropyl tartrate; MS 4 Angstroem; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)81547-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / (-)-diisopropyl tartrate, titanium tetraisopropoxide, t-butyl hydroperoxide, MS 4 Angstroem / CH2Cl2; toluene / 11 h / -20 °C
2: 91 percent / Red-al / toluene; tetrahydrofuran / 10.2 h / 0 °C
3: 93 percent / triethylamine, 4-DMAP / CH2Cl2 / 4 h / Ambient temperature
4: sodium hydride / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; (-)-diisopropyl tartrate; MS 4 Angstroem; sodium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)81547-7
