(2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide

Base Information

Chemical Name:(2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide
CAS No.:114469-40-8
Molecular Formula:C₂₃H₃₃NO₄
Molecular Weight:387.519
Hs Code.:

Synonyms:

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Chemical Property of (2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide

Chemical Property:

Purity/Quality:

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Technology Process of (2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide

There total 9 articles about (2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105852-88-8
2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2R)-butyric acid

: 114469-40-8
(2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1021/jm00117a027

Reference yield:

: 556-24-1
methyl 3-methylbutanoate

: 114469-40-8
(2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / diisopropylamine, n-butyllitium / tetrahydrofuran; hexamethylphosphoric acid triamide / 2.5 h / Ambient temperature

2: 51 percent / potassium tert-butoxide, H₂O / diethyl ether / 18 h / Ambient temperature

3: 1 N HCl / methanol

With hydrogenchloride; n-butyllithium; potassium tert-butylate; water; diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1021/jm00117a027

Reference yield:

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

: 114469-40-8
(2R,4S,5S)-5-benzyloxycarbonylamino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanolide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / diisopropylamine, n-butyllitium / tetrahydrofuran; hexamethylphosphoric acid triamide / 2.5 h / Ambient temperature

2: 51 percent / potassium tert-butoxide, H₂O / diethyl ether / 18 h / Ambient temperature

3: 1 N HCl / methanol

With hydrogenchloride; n-butyllithium; potassium tert-butylate; water; diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1021/jm00117a027