(S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

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Chemical Name:(S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine
CAS No.:106019-39-0
Molecular Formula:C₁₀H₁₇N*C₂₅H₃₂NO₆P
Molecular Weight:624.758
Hs Code.:

(S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

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Chemical Property of (S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

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Technology Process of (S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

There total 7 articles about (S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 106019-39-0
(S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / diphenylphosphoryl azide, triethylamine / dimethylformamide / 24 h / Ambient temperature

2: dicyclohexylcarbodiimide / pyridine / 1.5 h / 80 °C

3: diethyl ether

With diphenylphosphoranyl azide; triethylamine; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)84364-6

Reference yield:

: 89537-18-8
1-<(S)-2-hydroxy-1-oxopropyl>-L-proline phenylmethyl ester

: 106019-39-0
(S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / pyridine / 1.5 h / 80 °C

2: diethyl ether

With dicyclohexyl-carbodiimide; In pyridine; diethyl ether;
DOI:10.1016/S0040-4039(00)84364-6

Reference yield:

: 768-56-9
4-Phenylbut-1-ene

: 106019-39-0
(S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: NaH₂PO₂*H₂O, H₂SO₄, AIBN / ethanol / 16 h / Heating

2: dicyclohexylcarbodiimide, N,N-dimethylaminopyridine / tetrahydrofuran / 2 h / Ambient temperature

3: sodium metaperiodate / dioxane; H₂O / 16 h / Ambient temperature

4: diethyl ether

With dmap; sodium periodate; sodium hypophosphite; 2,2'-azobis(isobutyronitrile); sulfuric acid; dicyclohexyl-carbodiimide; isobutyric Acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water;
DOI:10.1016/S0040-4039(00)84364-6