6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

Base Information

Chemical Name:6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester
CAS No.:94405-66-0
Molecular Formula:C₄₃H₄₈Cl₃F₅N₄O₉
Molecular Weight:966.227
Hs Code.:

6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

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Chemical Property of 6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

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Technology Process of 6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

There total 9 articles about 6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3943-97-3
methyl 4-hydroxycinnamate

: 94405-66-0,94405-72-8
6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 8 steps

1: 57 percent / potassium ferricyanide/Na₂CO₃ / H₂O; CHCl₃

2: 74 percent / acetone / 25 °C

3: NaN₃/ICl / acetonitrile / 0 °C

4: tributyltin hydride / benzene / 20 h / 25 °C

5: 32 percent / chlorobenzene / 9 h / 132 °C

6: 90 percent / NaBH₃CN / acetic acid / 1.) 25 deg C, 2 h; 2.) 50 deg C, 1 h; 3.) 25 deg C, 12 h

7: barium hydroxide / tetrahydrofuran; methanol

8: DCC

With barium dihydroxide; sodium azide; tri-n-butyl-tin hydride; Iodine monochloride; sodium cyanoborohydride; sodium carbonate; dicyclohexyl-carbodiimide; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; chloroform; water; acetic acid; chlorobenzene; acetone; acetonitrile; benzene;
DOI:10.1021/ja00288a050

Reference yield:

: 84877-90-7
(E)-4-Methoxy-1,5,9-triaza-cyclotridec-4-ene-1,9-dicarboxylic acid 1-tert-butyl ester 9-(2,2,2-trichloro-ethyl) ester

: 94405-66-0,94405-72-8
6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 32 percent / chlorobenzene / 9 h / 132 °C

2: 90 percent / NaBH₃CN / acetic acid / 1.) 25 deg C, 2 h; 2.) 50 deg C, 1 h; 3.) 25 deg C, 12 h

3: barium hydroxide / tetrahydrofuran; methanol

4: DCC

With barium dihydroxide; sodium cyanoborohydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; acetic acid; chlorobenzene;
DOI:10.1021/ja00288a050

Reference yield:

: 94405-60-4
(2S,3S)-5-((E)-2-Methoxycarbonyl-vinyl)-2-(4-methoxy-phenyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

: 94405-66-0,94405-72-8
6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1,13-dicarboxylic acid 1-tert-butyl ester 13-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaN₃/ICl / acetonitrile / 0 °C

2: tributyltin hydride / benzene / 20 h / 25 °C

3: 32 percent / chlorobenzene / 9 h / 132 °C

4: 90 percent / NaBH₃CN / acetic acid / 1.) 25 deg C, 2 h; 2.) 50 deg C, 1 h; 3.) 25 deg C, 12 h

5: barium hydroxide / tetrahydrofuran; methanol

6: DCC

With barium dihydroxide; sodium azide; tri-n-butyl-tin hydride; Iodine monochloride; sodium cyanoborohydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; acetic acid; chlorobenzene; acetonitrile; benzene;
DOI:10.1021/ja00288a050