6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

Base Information

Chemical Name:6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid
CAS No.:94405-68-2
Molecular Formula:2C₂H₄O₂*C₄₀H₄₇F₅N₄O₇
Molecular Weight:910.933
Hs Code.:

6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

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Chemical Property of 6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

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Technology Process of 6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

There total 11 articles about 6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3943-97-3
methyl 4-hydroxycinnamate

: 94405-68-2,94405-74-0
6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 57 percent / potassium ferricyanide/Na₂CO₃ / H₂O; CHCl₃

2: 74 percent / acetone / 25 °C

3: NaN₃/ICl / acetonitrile / 0 °C

4: tributyltin hydride / benzene / 20 h / 25 °C

5: 32 percent / chlorobenzene / 9 h / 132 °C

6: 90 percent / NaBH₃CN / acetic acid / 1.) 25 deg C, 2 h; 2.) 50 deg C, 1 h; 3.) 25 deg C, 12 h

7: barium hydroxide / tetrahydrofuran; methanol

8: DCC

9: powdered zinc/acetic acid

With barium dihydroxide; sodium azide; tri-n-butyl-tin hydride; Iodine monochloride; sodium cyanoborohydride; sodium carbonate; acetic acid; dicyclohexyl-carbodiimide; potassium hexacyanoferrate(III); zinc; In tetrahydrofuran; methanol; chloroform; water; acetic acid; chlorobenzene; acetone; acetonitrile; benzene;
DOI:10.1021/ja00288a050

Reference yield:

: 84877-90-7
(E)-4-Methoxy-1,5,9-triaza-cyclotridec-4-ene-1,9-dicarboxylic acid 1-tert-butyl ester 9-(2,2,2-trichloro-ethyl) ester

: 94405-68-2,94405-74-0
6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 32 percent / chlorobenzene / 9 h / 132 °C

2: 90 percent / NaBH₃CN / acetic acid / 1.) 25 deg C, 2 h; 2.) 50 deg C, 1 h; 3.) 25 deg C, 12 h

3: barium hydroxide / tetrahydrofuran; methanol

4: DCC

5: powdered zinc/acetic acid

With barium dihydroxide; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; acetic acid; chlorobenzene;
DOI:10.1021/ja00288a050

Reference yield:

: 94405-60-4
(2S,3S)-5-((E)-2-Methoxycarbonyl-vinyl)-2-(4-methoxy-phenyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

: 94405-68-2,94405-74-0
6-[(2S,3S)-2-(4-Methoxy-phenyl)-3-pentafluorophenyloxycarbonyl-2,3-dihydro-benzofuran-5-yl]-8-oxo-1,5,9,13-tetraaza-cycloheptadecane-1-carboxylic acid tert-butyl ester; compound with acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NaN₃/ICl / acetonitrile / 0 °C

2: tributyltin hydride / benzene / 20 h / 25 °C

3: 32 percent / chlorobenzene / 9 h / 132 °C

4: 90 percent / NaBH₃CN / acetic acid / 1.) 25 deg C, 2 h; 2.) 50 deg C, 1 h; 3.) 25 deg C, 12 h

5: barium hydroxide / tetrahydrofuran; methanol

6: DCC

7: powdered zinc/acetic acid

With barium dihydroxide; sodium azide; tri-n-butyl-tin hydride; Iodine monochloride; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; acetic acid; chlorobenzene; acetonitrile; benzene;
DOI:10.1021/ja00288a050