LYRAPCFRANK

Base Information

• Chemical Name: LYRAPCFRANK
• CAS No.: 1356006-89-7
• Molecular Formula: C₆₀H₉₅N₁₉O₁₄S
• Molecular Weight: 1338.6
• Mol file: 1356006-89-7.mol

Synonyms:

Chemical Property of LYRAPCFRANK

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of LYRAPCFRANK

There total 9 articles about LYRAPCFRANK which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cys-Phe-Arg-Ala-Asn-Lys-OH (1278509-69-5) + LYRAP-S(CH2)2COOH → LYRAPCFRANK (1356006-89-7) + LYRCFRANK

Guidance literature:

With 4-mercaptophenylacetic acid; guanidine hydrochloride; tris-(2-carboxyethyl)-phosphine hydrochloride; sodium hydroxide; In aq. phosphate buffer; at 37 ℃; pH=7.1; Time;

DOI:10.1021/ol402678a

Reference yield:

Fmoc-Pro-OH (71989-31-6) → LYRAPCFRANK (1356006-89-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / Combinatorial reaction / High throughput screening (HTS)

1.2: Combinatorial reaction / High throughput screening (HTS)

2.1: tris-(2-carboxyethyl)-phosphine hydrochloride; sodium hydroxide / aq. acetate buffer / pH 4.1

3.1: aq. acetate buffer / 24 h / 65 °C / pH 4

4.1: 4-mercaptophenylacetic acid; guanidine hydrochloride; tris-(2-carboxyethyl)-phosphine hydrochloride; sodium hydroxide / aq. phosphate buffer / 37 °C / pH 7.1

With 4-mercaptophenylacetic acid; guanidine hydrochloride; tris-(2-carboxyethyl)-phosphine hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In aq. phosphate buffer;

DOI:10.1021/ol402678a

Reference yield:

LYRAP-SEAoff → LYRAPCFRANK (1356006-89-7) + LYRCFRANK

Guidance literature:

Multi-step reaction with 3 steps

1: tris-(2-carboxyethyl)-phosphine hydrochloride; sodium hydroxide / aq. acetate buffer / pH 4.1

2: aq. acetate buffer / 24 h / 65 °C / pH 4

3: 4-mercaptophenylacetic acid; guanidine hydrochloride; tris-(2-carboxyethyl)-phosphine hydrochloride; sodium hydroxide / aq. phosphate buffer / 37 °C / pH 7.1

With 4-mercaptophenylacetic acid; guanidine hydrochloride; tris-(2-carboxyethyl)-phosphine hydrochloride; sodium hydroxide; In aq. phosphate buffer;

DOI:10.1021/ol402678a

upstream raw materials:

Cys-Phe-Arg-Ala-Asn-Lys-OH

C₃₁H₄₉N₉O₇Se

C₃₄H₅₃N₉O₉S

1-(tert-butoxycarbonyl)-L-proline