4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide

Base Information

Chemical Name:4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide
CAS No.:1250871-99-8
Molecular Formula:C₃₁H₃₇N₅O₇S
Molecular Weight:623.73
Hs Code.:

Synonyms:

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Chemical Property of 4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide

Chemical Property:

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Technology Process of 4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide

There total 5 articles about 4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt

: 621-63-6
glycoaldehyde diethyl acetal

: 1250871-99-8
4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide

Guidance literature:: 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt; glycoaldehyde diethyl acetal; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 30 - 50 ℃;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil; at 30 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

: 150728-12-4
5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidine-4,6(1H, 5H)-dione

: 1250871-99-8
4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 4 h / Reflux

2.1: potassium hydroxide / acetone / 0.08 h / 30 °C

2.2: 6.5 h / 30 °C / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 30 - 50 °C

3.2: 0.5 h / 30 °C

With sodium hydride; potassium hydroxide; trichlorophosphate; In N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 150726-89-9
(2-methoxyphenoxy)-malonic acid dimethyl ester

: 1250871-99-8
4-tert-butyl-N-[6-(2,2-diethoxy-ethoxy)-5-(2-methoxyphenoxy)-[2,2']bipyrimidin-4-yl]-benzene sulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 3 h / 25 - 30 °C

1.2: 3 h / 25 - 30 °C

2.1: trichlorophosphate / 4 h / Reflux

3.1: potassium hydroxide / acetone / 0.08 h / 30 °C

3.2: 6.5 h / 30 °C / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 30 - 50 °C

4.2: 0.5 h / 30 °C

With sodium methylate; sodium hydride; potassium hydroxide; trichlorophosphate; In methanol; N,N-dimethyl-formamide; acetone; mineral oil;