N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

Base Information

Chemical Name:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide
CAS No.:1467052-75-0
Molecular Formula:BrH*C₃₄H₄₄N₄O₄
Molecular Weight:653.66
Hs Code.:

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

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Suppliers and Price of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

There total 8 articles about N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403254-99-8
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-4-methyl-4’-(morpholinomethyl)-[1,1 ‘-biphenyl]-3-carboxamide

: 1467052-75-0
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

Guidance literature:: With hydrogen bromide; In ethanol; water; at 70 ℃; for 0.5h;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1467052-75-0
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 20 - 60 °C

3.1: ammonium chloride / ethanol; water / 80 °C

3.2: 12 h / 80 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2.5 h / 25 - 40 °C

5.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 20 °C

5.2: 3 h / 0 - 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 17 h / 20 - 89 °C / Inert atmosphere

7.1: sodium hydroxide; water / ethanol / 18 h / 40 °C

8.1: triethylamine / dimethyl sulfoxide / 0.5 h / 25 °C

8.2: 16 h / 20 °C

9.1: hydrogen bromide / ethanol; water / 0.5 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; hydrogen bromide; sodium tris(acetoxy)borohydride; sodium carbonate; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1467052-75-0
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)[1,1‘-biphenyl]-3-carboxamide hydrobromide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 20 - 60 °C

2.1: ammonium chloride / ethanol; water / 80 °C

2.2: 12 h / 80 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2.5 h / 25 - 40 °C

4.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 20 °C

4.2: 3 h / 0 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 17 h / 20 - 89 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 18 h / 40 °C

7.1: triethylamine / dimethyl sulfoxide / 0.5 h / 25 °C

7.2: 16 h / 20 °C

8.1: hydrogen bromide / ethanol; water / 0.5 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; hydrogen bromide; sodium tris(acetoxy)borohydride; sodium carbonate; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;