EPZ-6438

Base Information

Chemical Name:EPZ-6438
CAS No.:1403254-99-8
Molecular Formula:C34H44N4O4
Molecular Weight:572.748
Hs Code.:
Mol file:1403254-99-8.mol

Synonyms:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide;S7128,E7438;EPZ-6438;EPZ-6438 (E7438);

Suppliers and Price of EPZ-6438

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EPZ6438
1mg
$ 50.00

DC Chemicals
Tazemetostat(EPZ-6438) >98%
100 mg
$ 350.00

DC Chemicals
Tazemetostat(EPZ-6438) >98%
250 mg
$ 600.00

Crysdot
EPZ-6438 98+%
100mg
$ 358.00

Crysdot
EPZ-6438 98+%
250mg
$ 626.00

Crysdot
EPZ-6438 98+%
50mg
$ 216.00

ChemScene
Tazemetostat 99.93%
10mg
$ 84.00

ChemScene
Tazemetostat 99.93%
50mg
$ 120.00

ChemScene
Tazemetostat 99.93%
5mg
$ 60.00

ChemScene
Tazemetostat 99.93%
100mg
$ 190.00

Total 46 raw suppliers

Chemical Property of EPZ-6438

Chemical Property:

Boiling Point:750.8±60.0 °C(Predicted)
PKA:11.92±0.10(Predicted)
PSA：90.65000
Density:1.163±0.06 g/cm3(Predicted)
LogP:5.65960
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (up to at least 25 mg/ml).

Purity/Quality:

99%, ^*data from raw suppliers

EPZ6438 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Tazemetostat (1403254-99-8) is a potent (Ki = 2.5nM wild type human PRC2-containing) and selective SAM-competitive inhibitor of the lysine methyltransferase EZH2.1?Tazemetostat displayed strong antiproliferative effects against SMARCB1-deleted malignant rhabdoid tumor (MRT) cell lines?in vitro. This antitumor activity was also observed in SMARTCB1 mutant mouse xenografts. It displayed potent antitumor activity in various cancer models including non-Hodgkins lymphoma2, pediatric glioma3, small-cell carcinoma of the ovary4, and synovial sarcomas5. Tazemetostat has also been shown to control inflammatory genes by modulating IRF1, IRF8, and STAT1 levels suggesting therapeutic potential for the treatment of neuroinflammatory diseases associated with microglial activation.6
Uses EPZ 6438 is a potent and selective inhibitor of EZH2.

Technology Process of EPZ-6438

There total 16 articles about EPZ-6438 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1‘-biphenyl]-3-carboxylic acid

: 3-(aminomethyl)-4,6-dimethyl-dihydro-pyridin-2(1H)-one hydrochloride

: 1403254-99-8
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-4-methyl-4’-(morpholinomethyl)-[1,1 ‘-biphenyl]-3-carboxamide

Guidance literature:: 5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1‘-biphenyl]-3-carboxylic acid; 3-(aminomethyl)-4,6-dimethyl-dihydro-pyridin-2(1H)-one hydrochloride; With triethylamine; In dimethyl sulfoxide; at 25 ℃; for 0.5h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 16h;

Reference yield: 90.0%

: 1173081-96-3
(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methylamine hydrochloride

: 5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1‘-biphenyl]-3-carboxylic acid

: 1403254-99-8
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-4-methyl-4’-(morpholinomethyl)-[1,1 ‘-biphenyl]-3-carboxamide

Guidance literature:: (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methylamine hydrochloride; 5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1‘-biphenyl]-3-carboxylic acid; With triethylamine; In dimethyl sulfoxide; at 15 - 25 ℃; for 0.5h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; for 16h;

With triethylamine; In water; dimethyl sulfoxide; at 19 - 30 ℃; for 4h;

Reference yield: 71.0%

: 1403257-80-6
5-bromo-N-((4, 6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzamide

: 364794-79-6
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]morpholine

: 1403254-99-8
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-4-methyl-4’-(morpholinomethyl)-[1,1 ‘-biphenyl]-3-carboxamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile; at 100 ℃; for 4h; Inert atmosphere;