Technology Process of C20H21NO5
There total 3 articles about C20H21NO5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-benzyl 3-(benzyloxycarbonylamino)-4-hydroxybutanoate;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.416667h;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
at -78 ℃;
for 0.25h;
Inert atmosphere;
DOI:10.1055/s-0032-1318344
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / methanol; water / 0.25 h / -15 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
2.2: 0.25 h / -78 °C / Inert atmosphere
With
sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide;
In
methanol; dichloromethane; water;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1055/s-0032-1318344
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere
2.1: sodium tetrahydroborate / methanol; water / 0.25 h / -15 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
3.2: 0.25 h / -78 °C / Inert atmosphere
With
4-methyl-morpholine; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1055/s-0032-1318344
