Azido-PEG5-CH2CO2t-butyl ester

Base Information

• Chemical Name: Azido-PEG5-CH2CO2t-butyl ester
• CAS No.: 1448451-72-6
• Molecular Formula: C₁₆H₃₁N₃O₇
• Molecular Weight: 377.438
• Mol file: 1448451-72-6.mol

Synonyms:

Chemical Property of Azido-PEG5-CH2CO2t-butyl ester

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Azido-PEG5-CH2CO2t-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG5-CH2CO2-t-Bu consist of an azide group(N3) and a t-butyl ester.The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. PEG spacer increases solubility in aqueous media.

Technology Process of Azido-PEG5-CH2CO2t-butyl ester

There total 14 articles about Azido-PEG5-CH2CO2t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 17-(tosyloxy)-3,6,9,12,15-pentaoxaheptadecan-1-oate → tert-butyl 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-oate (1448451-72-6)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 47.0%

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid (217180-81-9) + tert-butyl alcohol (75-65-0) → tert-butyl 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-oate (1448451-72-6)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 39.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol (86770-67-4) → tert-butyl 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-oate (1448451-72-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

DOI:10.1016/j.bmc.2019.115228

upstream raw materials:

17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol

tert-butyl alcohol

17-chloro-3,6,9,12,15-pentaoxaheptadecan-1-ol

tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oate

Downstream raw materials:

[2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1448451-72-6 Azido-PEG5-CH2CO2t-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send