3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-azido-

Base Information

• Chemical Name: 3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-azido-
• CAS No.: 217180-81-9
• Molecular Formula: C₁₂H₂₃N₃O₇
• Molecular Weight: 321.331
• Mol file: 217180-81-9.mol

Synonyms:N3-PEG5-CH2COOH;N3-PEG5-CH2CO2H;Azido-PEG5-CH2CO2H;AZIDE-PEG5-CH2COOH;Azido-PEG5-CH2COOH;17-azido-3,6,9,12,15-pentaoxaheptadecanoic acid

Chemical Property of 3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-azido-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N3-PEG5-CH2COOH 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG5-CH2CO2H is a water soluble PEG linker. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide.

Technology Process of 3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-azido-

There total 18 articles about 3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-azido- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C13H25N3O7 → 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid (217180-81-9)

Guidance literature:

With water; sodium hydroxide; In methanol; at 0 - 20 ℃; for 3h;

Reference yield: 89.0%

17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol (86770-69-6) → 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid (217180-81-9)

Guidance literature:

With Jones reagent; In acetone; at -5 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5) + bromoacetic acid (79-08-3) → 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid (217180-81-9)

Guidance literature:

14-azido-3,6,9,12-tetraoxatetradecan-1-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h;

bromoacetic acid; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.bmc.2022.116707

upstream raw materials:

17-bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol

pentaethylene glycol

toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester

17-iodo-3,6,9,12,15-pentaoxaheptadecan-1-ol

Downstream raw materials:

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid