1-acetyl-2-methyl-aziridine

Base Information

• Chemical Name: 1-acetyl-2-methyl-aziridine
• CAS No.: 123620-68-8
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.1326
• Mol file: 123620-68-8.mol

Synonyms:

Chemical Property of 1-acetyl-2-methyl-aziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-2-methyl-aziridine

There total 2 articles about 1-acetyl-2-methyl-aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetyl chloride (75-36-5) + 2-Methylaziridine (75-55-8,41927-28-0,76612-76-5,76612-77-6,205537-16-2) → 1-acetyl-2-methyl-aziridine (123620-68-8,13416-47-2)

Guidance literature:

With triethylamine; In Petroleum ether; at 0 ℃; for 0.75h; Yield given;

DOI:10.1016/S0040-4039(01)80033-2

Reference yield:

Ketene (463-51-4) + 2-Methylaziridine (75-55-8,41927-28-0,76612-76-5,76612-77-6,205537-16-2) → 1-acetyl-2-methyl-aziridine (123620-68-8,13416-47-2)

Guidance literature:

With diethyl ether;

DOI:10.1021/jo01095a022

Reference yield: 100.0%

1-acetyl-2-methyl-aziridine (123620-68-8,13416-47-2) + carbon dioxide (124-38-9,18923-20-1) → (R,S)-2,4-dimethyl-2-oxazoline (6159-23-5)

Guidance literature:

for 16.65h; regioselective reaction; High speed ball milling; Neat (no solvent); Sealed vessel;

DOI:10.1039/c1gc15850c

upstream raw materials:

Ketene

2-Methylaziridine

acetyl chloride

Downstream raw materials:

non-3-yn-2-one

acetophenone

(R,S)-2,4-dimethyl-2-oxazoline

Refernces

• 1、 Fanta,Deutsch. "-". . p. 72. Retrieved 1958.