N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol

Base Information

Chemical Name:N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol
CAS No.:134786-29-1
Molecular Formula:C₁₉H₂₉NO₃S
Molecular Weight:351.51
Hs Code.:

Synonyms:

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Chemical Property of N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol

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Technology Process of N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol

There total 18 articles about N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 134786-19-9
N-tosyl-1-(2,3-epoxy-3-methylbutyl)cyclohexane-methylamine

: 134786-29-1
N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol

Guidance literature:: With sodium hydroxide; for 0.0833333h; Heating;
DOI:10.1016/S0040-4020(01)96036-3

Reference yield:

: 4630-82-4
methyl cyclohexylcarboxylate

: 134786-29-1
N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / iPr₂NLi / tetrahydrofuran / 2 h / -78 °C

2: 92 percent / 15percent ethanolic KOH / 48 h / Heating

3: sodium, oxalyl chloride / diethyl ether / 3 h / Heating

4: ammonia / diethyl ether / ice-cooling

5: 83 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

6: 83 percent / 25percent NaOH / dimethylformamide; H₂O / 1 h / pH 12

7: 1) m-chloroperbenzoic acid, 2) potassium carbonate / 1) chloroform, room temperature, 2) 0 deg C, 2 h

8: 89 percent / CrO₃, H₂SO₄, H₂O / acetone / a) -5 deg C, 3 h, b) room temperature, 5 h

9: methanol

With chromium(VI) oxide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; sulfuric acid; ammonia; water; sodium; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)96036-3

Reference yield:

: 134786-08-6
1-(2-methylprop-2-enyl)cyclohexane-methylamine

: 134786-29-1
N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / 25percent aq. NaOH / dimethylformamide; H₂O / 1 h / pH 12

2: 1) m-chloroperbenzoic acid, 2) potassium carbonate / 1) chloroform, room temperature, 2) 0 deg C, 2 h

3: 1) BF₃*Et₂O, 2) H₂O / 1) a) dichloromethane, -78 deg C, 3.5 h, b) room temperature, 18 h

With sodium hydroxide; boron trifluoride diethyl etherate; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96036-3