Technology Process of trans-1-(4-methoxyphenyl)-3(a),4(a)-diazetoxyquinolizidine
There total 7 articles about trans-1-(4-methoxyphenyl)-3(a),4(a)-diazetoxyquinolizidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / ethanol; H2O / 1.5 h / 4 °C
2: ethanol / Heating
3: 33 percent / 2.3M BuLi / hexane; diethyl ether / 0 °C
4: 1.) trifluoroacetic anhydride, 50percent aq. H2O2, 2.) acetic acid / 1.) dichloromethane, trifluoroacetic acid, 23 deg C, 3 h, then room temp., 6 days, 2.) 23 deg C, 3 days
With
sodium hydroxide; n-butyllithium; dihydrogen peroxide; acetic acid; trifluoroacetic anhydride;
In
diethyl ether; ethanol; hexane; water;
DOI:10.1021/jo00174a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / benzene / 2 h / Heating
3: 33 percent / 2.3M BuLi / hexane; diethyl ether / 0 °C
4: 1.) trifluoroacetic anhydride, 50percent aq. H2O2, 2.) acetic acid / 1.) dichloromethane, trifluoroacetic acid, 23 deg C, 3 h, then room temp., 6 days, 2.) 23 deg C, 3 days
With
n-butyllithium; dihydrogen peroxide; acetic acid; trifluoroacetic anhydride;
In
diethyl ether; hexane; benzene;
DOI:10.1021/jo00174a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / ethanol; H2O / 1.5 h / 4 °C
2: ethanol / Heating
3: 33 percent / 2.3M BuLi / hexane; diethyl ether / 0 °C
4: 1.) trifluoroacetic anhydride, 50percent aq. H2O2, 2.) acetic acid / 1.) dichloromethane, trifluoroacetic acid, 23 deg C, 3 h, then room temp., 6 days, 2.) 23 deg C, 3 days
With
sodium hydroxide; n-butyllithium; dihydrogen peroxide; acetic acid; trifluoroacetic anhydride;
In
diethyl ether; ethanol; hexane; water;
DOI:10.1021/jo00174a009
