benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide

Base Information

• Chemical Name: benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide
• CAS No.: 614734-69-9
• Molecular Formula: C₂₆H₂₆N₂OS₂
• Molecular Weight: 446.637
• Mol file: 614734-69-9.mol

Synonyms:

Chemical Property of benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide

There total 4 articles about benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzothiophene-2-carboxylic acid chloride (39827-11-7) → benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide (614734-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: solid-supported BH₃; AcOH / acetonitrile; H₂O

With borane; acetic acid; In water; acetonitrile;

DOI:10.1016/S0960-894X(03)00554-7

Reference yield:

2-(benzylsulfanyl)aniline (6325-92-4) → benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide (614734-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: solid-supported BH₃; AcOH / acetonitrile; H₂O

With borane; acetic acid; In water; acetonitrile;

DOI:10.1016/S0960-894X(03)00554-7

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + benzo[b]thiophene-2-carboxylic acid (3-amino-propyl)-(2-benzylsulfanyl-phenyl)-amide → benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide (614734-69-9)

Guidance literature:

With borane; acetic acid; In water; acetonitrile;

DOI:10.1016/S0960-894X(03)00554-7

upstream raw materials:

formaldehyd

N-methyl-3-hydroxypropylamine

benzothiophene-2-carboxylic acid chloride

2-(benzylsulfanyl)aniline