(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

Base Information

Chemical Name:(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate
CAS No.:1075234-83-1
Molecular Formula:C₇H₆O₂*C₂₂H₂₄N₆O₃S
Molecular Weight:574.66
Hs Code.:

(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

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Chemical Property of (1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

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Technology Process of (1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

There total 18 articles about (1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075234-80-8
(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione hydrochloride

: 65-85-0,8013-63-6
benzoic acid

: 1075234-83-1
(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

Guidance literature:: In methanol; for 1h;

Reference yield:

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 1075234-83-1
(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

Guidance literature:: Multi-step reaction with 14 steps

1.1: ammonia / methanol / 18 h / 65 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 760.05 Torr

3.1: potassium carbonate / acetonitrile / 20 °C

4.1: sodium hydrogencarbonate / water; ethyl acetate / 0.75 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

5.2: 1 h

6.1: N,N-dimethyl-formamide / 120 - 130 °C

7.1: hydrogen / palladium on activated charcoal / ethanol / 3 h / 20 °C / 760.05 Torr

8.1: manganese(IV) oxide / methanol; dichloromethane / 5 h / 20 °C

9.1: triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

10.1: pyridine / acetonitrile / 20 - 90 °C

11.1: hydrogenchloride / 1,4-dioxane; chloroform / 0.5 h / 20 °C

12.1: triethylamine / methanol; chloroform / 0.25 h / 20 °C

12.2: 0.5 h

13.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

14.1: methanol / 1 h

With pyridine; hydrogenchloride; manganese(IV) oxide; ammonia; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1073634-29-3
phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate

: 1075234-83-1
(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

1.2: 1 h

2.1: N,N-dimethyl-formamide / 120 - 130 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 3 h / 20 °C / 760.05 Torr

4.1: manganese(IV) oxide / methanol; dichloromethane / 5 h / 20 °C

5.1: triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

6.1: pyridine / acetonitrile / 20 - 90 °C

7.1: hydrogenchloride / 1,4-dioxane; chloroform / 0.5 h / 20 °C

8.1: triethylamine / methanol; chloroform / 0.25 h / 20 °C

8.2: 0.5 h

9.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

10.1: methanol / 1 h

With pyridine; hydrogenchloride; manganese(IV) oxide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;