phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate

Base Information

• Chemical Name: phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate
• CAS No.: 1073634-29-3
• Molecular Formula: C₁₆H₁₅N₃O₄
• Molecular Weight: 313.313
• Mol file: 1073634-29-3.mol

Synonyms:phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate

Chemical Property of phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate

There total 3 articles about phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-(methyloxy)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one (1073633-84-7) + benzyl chloroformate (501-53-1,94274-21-2) → phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate (1073634-29-3)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 0.75h;

Reference yield:

2,3-diamino-6-methoxypyridine (28020-38-4) → phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate (1073634-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 20 °C

2: potassium tert-butylate / tetrahydrofuran / 1.5 - 2 h / 0 - 20 °C

3: sodium hydrogencarbonate / water; ethyl acetate / 0.75 h / 20 °C

With potassium tert-butylate; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; ethyl acetate; acetonitrile;

Reference yield:

ethyl N-[2-amino-6-(methyloxy)-3-pyridinyl]glycinate (1073633-83-6) → phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate (1073634-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 1.5 - 2 h / 0 - 20 °C

2: sodium hydrogencarbonate / water; ethyl acetate / 0.75 h / 20 °C

With potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

upstream raw materials:

6-(methyloxy)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one

benzyl chloroformate

ethyl N-[2-amino-6-(methyloxy)-3-pyridinyl]glycinate

2,3-diamino-6-methoxypyridine

Downstream raw materials:

(1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

phenylmethyl (1S)-1-{[(methylsulfonyl)oxy]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

phenylmethyl (1S)-1-(hydroxymethyl)-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate