C₁₄H₁₅BN₂O₅

Base Information

• Chemical Name: C₁₄H₁₅BN₂O₅
• CAS No.: 1364267-61-7
• Molecular Formula: C₁₄H₁₅BN₂O₅
• Molecular Weight: 302.094
• Mol file: 1364267-61-7.mol

Synonyms:

Chemical Property of C₁₄H₁₅BN₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₅BN₂O₅

There total 5 articles about C₁₄H₁₅BN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(2-amino-5-bromopyridin-3-yl)-2-methoxybenzoate (1364267-50-4) → C14H15BN2O5 (1364267-61-7)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h; Microwave irradiation;

DOI:10.1021/jm201683b

Reference yield:

methyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (603122-40-3) → C14H15BN2O5 (1364267-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; bis(pinacol)diborane; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm201683b

Reference yield:

4-bromosalicylic acid (1666-28-0) → C14H15BN2O5 (1364267-61-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid / 24 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium acetate; sodium hydrogencarbonate; potassium carbonate; bis(pinacol)diborane; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm201683b

upstream raw materials:

methyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

methyl 4-(2-amino-5-bromopyridin-3-yl)-2-methoxybenzoate

4-bromosalicylic acid

4-bromo-2-Hydroxybenzoic Acid Methylester

Downstream raw materials:

methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzamide

Refernces