Technology Process of dibenzyl (2S,3R)-2-benzyl-3-hydroxysuccinate
There total 2 articles about dibenzyl (2S,3R)-2-benzyl-3-hydroxysuccinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / toluene-p-sulfonic acid monohydrate / toluene / Heating
2: 1.) lithium diisopropylamide / 1) hexane, THF, -78 deg C, 1 h; 2) THF, hexane, -78 deg C, 1 h, -50 deg C, 5 h
With
toluene-4-sulfonic acid; lithium diisopropyl amide;
In
toluene;
DOI:10.1039/P19950002877
- Guidance literature:
-
With
lithium diisopropyl amide;
Yield given. Multistep reaction;
1) hexane, THF, -78 deg C, 1 h; 2) THF, hexane, -78 deg C, 1 h, -50 deg C, 5 h;
DOI:10.1039/P19950002877
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) boran, methyl sulfide, 2.) NaBH4 / 1) THF, 1 h; 2) THF, 30 min, room temperature
2: 89 percent / pyridine, methanesulfonyl chloride / CH2Cl2 / 48 h
3: 95 percent / H2 / Pd-C / methanol / 1 h
With
pyridine; sodium tetrahydroborate; dimethylsulfide; borane; hydrogen; methanesulfonyl chloride;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1039/P19950002877
