2-(3-Fluoro-4-methoxyphenyl)propanoic acid

Base Information

Chemical Name:2-(3-Fluoro-4-methoxyphenyl)propanoic acid
CAS No.:79281-00-8
Molecular Formula:C₁₀H₁₁FO₃
Molecular Weight:198.194
Hs Code.:
European Community (EC) Number:821-483-1

Synonyms:2-(3-fluoro-4-methoxyphenyl)propanoic acid;79281-00-8;SCHEMBL3667658;AKOS010488466;2-(3-fluoro-4-methoxyphenyl)propanoicacid;CS-0223072;G45196;EN300-1137970;Z792377220

Suppliers and Price of 2-(3-Fluoro-4-methoxyphenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-(3-Fluoro-4-methoxyphenyl)propanoic acid

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:198.06922237
Heavy Atom Count:14
Complexity:208

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)OC)F)C(=O)O

Technology Process of 2-(3-Fluoro-4-methoxyphenyl)propanoic acid

There total 5 articles about 2-(3-Fluoro-4-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127414-08-8
ethyl 2-cyano-2-(3-fluoro-4-methoxyphenyl)propionate

: 79281-00-8
2-(3-fluoro-4-methoxyphenyl)propanoic acid

Guidance literature:: With potassium hydroxide; water; In ethanol; for 10h; Heating;

Reference yield:

: 321-28-8
1-fluoro-2-methoxybenzene

: 79281-00-8
2-(3-fluoro-4-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: HCl (gas), ZnCl₂ / acetic acid / 8 h / Heating

2: 90 percent / dimethylsulfoxide / 3 h / 40 - 45 °C

3: NaOEt / ethanol / 95 - 125 °C

4: NaOEt / ethanol / 1.) 40 deg C, 3 h, 2.) reflux, 3 h

5: H₂O, KOH / ethanol / 10 h / Heating

With hydrogenchloride; potassium hydroxide; water; sodium ethanolate; zinc(II) chloride; In ethanol; acetic acid; dimethyl sulfoxide;

Reference yield:

: 351-52-0
3-fluoro-4-methoxybenzyl chloride

: 79281-00-8
2-(3-fluoro-4-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / dimethylsulfoxide / 3 h / 40 - 45 °C

2: NaOEt / ethanol / 95 - 125 °C

3: NaOEt / ethanol / 1.) 40 deg C, 3 h, 2.) reflux, 3 h

4: H₂O, KOH / ethanol / 10 h / Heating

With potassium hydroxide; water; sodium ethanolate; In ethanol; dimethyl sulfoxide;