Multi-step reaction with 12 steps
1: hydrogen / palladium(II) hydroxide / ethyl acetate; tetrahydrofuran / 4.5 h / 760.05 Torr
2: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C
3: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 20 °C / Cooling with ice
4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide
5: n-butyllithium / tetrahydrofuran
6: sodium carbonate / ethanol
7: Iodine monochloride / dichloromethane
8: potassium phosphate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water
9: tetrabutyl ammonium fluoride; acetic acid / water; tetrahydrofuran
10: sodium hydrogencarbonate; Dess-Martin periodane / chloroform
11: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water
12: hydrogen bromide; acetic acid
With
1H-imidazole; potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; dihydrogen peroxide; Iodine monochloride; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; palladium(II) hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;