1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)-

Base Information

Chemical Name:1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)-
CAS No.:139689-10-4
Molecular Formula:C19H21NO2
Molecular Weight:295.381
Hs Code.:
UNII:Z6L0619NIB
Nikkaji Number:J482.833J
Wikidata:Q27295071
Pharos Ligand ID:W71LC4UFW2BH
ChEMBL ID:CHEMBL286120

Synonyms:SKF-77434, (S)-;139689-10-4;S-(-)-Apd;Z6L0619NIB;UNII-Z6L0619NIB;S-(-)-SKF-77434;J482.833J;CHEMBL286120;1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)-;(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol;(1S,(-))-2,3,4,5-Tetrahydro-3-(2-propenyl)-1alpha-phenyl-1H-3-benzazepine-7,8-diol;Tocris-1662;Lopac-S-168;(S)-skf-77434;BDBM50004924;(5S)-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;AKOS040746350;NCGC00015915-01;NCGC00015915-02;NCGC00025249-01;PD132207;Q27295071;[1S,(?)]-2,3,4,5-Tetrahydro-3-(2-propenyl)-1alpha-phenyl-1H-3-benzazepine-7,8-diol;S-(-)-APD3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol;(1S,(-))-2,3,4,5-TETRAHYDRO-3-(2-PROPENYL)-1.ALPHA.-PHENYL-1H-3-BENZAZEPINE-7,8-DIOL

Suppliers and Price of 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:295.157228913
Heavy Atom Count:22
Complexity:366

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C=CCN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O
Isomeric SMILES:C=CCN1CCC2=CC(=C(C=C2[C@@H](C1)C3=CC=CC=C3)O)O

Technology Process of 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)-

There total 5 articles about 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 139689-07-9
(S)-(-)-3-allyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

: 139689-10-4
(-)-SKF 77434

Guidance literature:: With boron tribromide; In hexane; dichloromethane; 1.) -70 deg C, 1 h, 2.) RT, 2 h;
DOI:10.1021/jm00086a016

Reference yield:

: 20569-49-7
7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 139689-10-4
(-)-SKF 77434

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 88percent aq. formic acid / 4 h / Heating

3: 1.) cyanogen bromide, 2.) 3N aq. HCl, glacial acetic acid / 1.) benzene, 55-60 deg C, 4 h, 2.) reflux, 24 h

4: 58 percent / K₂CO₃ / dimethylformamide; H₂O; CH₂Cl₂ / Ambient temperature

5: 62 percent / boron tribromide / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h

With hydrogenchloride; formic acid; bromocyane; boron tribromide; potassium carbonate; acetic acid; In hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a016

Reference yield:

: 20012-08-2
1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydro-3H-benzazepine

: 139689-10-4
(-)-SKF 77434

Guidance literature:: Multi-step reaction with 4 steps

2: 1.) cyanogen bromide, 2.) 3N aq. HCl, glacial acetic acid / 1.) benzene, 55-60 deg C, 4 h, 2.) reflux, 24 h

3: 58 percent / K₂CO₃ / dimethylformamide; H₂O; CH₂Cl₂ / Ambient temperature

4: 62 percent / boron tribromide / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h

With hydrogenchloride; bromocyane; boron tribromide; potassium carbonate; acetic acid; In hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a016