20012-08-2

Basic information

• Product Name: trimopam
• Synonyms: trimopam;7,8-diMethoxy-3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
• CAS NO: 20012-08-2
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.396
• Mol File: 20012-08-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 80-81 °C
• Boiling Point: 416.8°C at 760 mmHg
• Flash Point: 137.5°C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 3.72E-07mmHg at 25°C
• Refractive Index: 1.555
• PKA: 8.18±0.40(Predicted)
• CAS DataBase Reference: trimopam(CAS DataBase Reference)
• NIST Chemistry Reference: trimopam(20012-08-2)
• EPA Substance Registry System: trimopam(20012-08-2)

Safety Data

• Hazardous Substances Data: 20012-08-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H23NO2/c1-20-10-9-15-11-18(21-2)19(22-3)12-16(15)17(13-20)14-7-5-4-6-8-14/h4-8,11-12,17H,9-10,13H2,1-3H3

Upstream product

• 1147090-63-8 2-(N-3,4-dimethoxyphenethyl-N-methylamino)-1-phenylethyl N',N'-diisopropylcarbamate 
• 78495-54-2 7,8-dimethoxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 108-90-7 chlorobenzene 
• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 20569-49-7 7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 20011-97-6 N-[2-(3,4-dimethoxyphenyl)ethyl]-2-phenyl-2-hydroxyethylamine 
• 96-09-3 styrene oxide 
• 124608-93-1 trans-1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-1-methylthio-5-phenyl-2H-3-benzazepin-2-one 
• 90530-87-3 2-(3,4-dimethoxyphenyl)-N-methyl-2-phenylethylamine 
• 124608-92-0 N-<2-(3,4-dimethoxyphenyl)-2-phenylethyl>-N-methyl-2-(methylsulfinyl)acetamide 
• 124608-91-9 N-<2-(3,4-dimethoxyphenyl)-2-phenylethyl>-N-methyl-2-(methylthio)acetamide 
• 17777-02-5 (3,4-dimethoxyphenyl)phenylacetic acid 
• 124608-96-4 trans-2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-1-methylthio-5-phenyl-1H-3-benzazepine 

Downstream Products

• 56030-50-3 (+)-(R)-1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydro-3H-benzazepine 
• 62717-89-9 (-)-(S)-1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydro-3H-benzazepine 
• 81633-72-9 (S)-2,3,4,5-tetrahydro-7,8-dihydroxy-3-methyl-1-phenyl-1H-3-benzazepine hydrobromide 
• 62717-63-9 (R)-2,3,4,5-tetrahydro-7,8-dihydroxy-3-methyl-1-phenyl-1H-3-benzazepine hydrobromide 
• 62717-91-3 (S)-3-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1H-3-benzazepine 
• 62717-92-4 (R)-3-benzyl-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1H-3-benzazepine 
• 62717-13-9 (R)-3-benzyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 
• 77969-27-8 (S)-3-cyano-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1H-3-benzazepine 
• 81633-75-2 (R)-3-cyano-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1H-3-benzazepine 
• 139689-17-1 (-)-6-Br-APB hydrobromide 
• 139689-19-3 (+)-6-Br-APB hydrobromide 
• 139689-15-9 (S)-(-)-3-allyl-6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 139689-16-0 (R)-(+)-3-allyl-6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 139689-07-9 (S)-(-)-3-allyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride 

Relevant articles and documents

Aryne-Mediated Arylation of the 3-Benzazepine Scaffold: One-Pot Synthesis of 1-Aryl-3-methyl-2,3,4,5-tetrahydro-1 H -3-benzazepines

The coupling of β-amino carbanions derived from 3-benzA"azeA"pines with in situ generated arynes has been demonstrated as a convenient route for the direct synthesis of a variety of 1-aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines, including the biologically active drug molecule SCH 12679.

Rearrangements of 1,6,7-Trisubstituted 2-Methyl-1,2,3,4-tetrahydroisoquinolinium 2-Methylides

Chemical behavior of 1,6,7-trisubstituted 2-methy-1,2,3,4-tetrahydroisoquinolinium 2-methylides 4 was investigated in fluoride-ion induced desilation reaction of 1,6,7-trisubstituted 2-methyl-2-(trimethylsilyl)methyl-1,2,3,4-tetrahydroisoquinolinium iodid

Tricarbonylchromium(0) Promoted Stereoselective Cyclisations of the N-3,4-Dimethoxyphenethyl Derivatives of the 1-Phenyl Ethanolamines Halostachine, Ephedrine and Pseudoephedrine to 1-Phenyl-N-Methyl-7,8-Dimethoxy-1,2,4,5-Tetrahydrobenzazepines

Acid promoted cyclisation of homochiral (R)-N-(3,4-dimethoxyphenethyl)-halostachine proceeds with almost total racemisation to yield 1-phenyl-N-methyl-1,2,4,5-tetrahydrobenzazepine (e.e, 6percent).Coordination of the cyclisation precursor to the tricarbonylchromium(0) moiety renders the cyclisation completely stereospecific to afford, after decomplexation, homochiral (+)-(R)-1-phenyl-N-methyl-1,2,4,5-tetrahydrobenzazepine. (-)-(1R,2S)-N-(3,4-Dimethoxyphenethyl)ephedrine undergoes acid mediated cyclisation to furnish trans-(-)-(1R,2S)-1-phenyl-2-methyl-N-methyl-7,8-dimethoxy tetrahydrobenzazepine as a single diastereoisomer.In contrast, the epimeric cyclisation precursor (-)-(1R,2R)-N-(3,4-dimethoxyphenethyl)pseudoephedrine cyclises to give a mixture (ratio 91:9) of trans- and cis-1-phenyl-2-methyl-N-methyl-7,8-dimethoxy tetrahydrobenzazepine.However, cyclisation of the tricarbonylchromium(0) complex of (-)-(1R,2R)-N-(3,4-dimethoxyphenethyl)pseudo-ephedrine is completely stereoselective to yield trans-(+)-(1S,2R)-1-phenyl-2-methyl-N-methyl-7,8-dimethoxy tetrahydrobenzazepine after decomplexation.