2-[(2-Hydroxyphenyl)amino]acetonitrile

Base Information

• Chemical Name: 2-[(2-Hydroxyphenyl)amino]acetonitrile
• CAS No.: 28363-25-9
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• DSSTox Substance ID: DTXSID901296685

Synonyms:SCHEMBL6805636;DTXSID901296685;AKOS006359594;2-[(2-Hydroxyphenyl)amino]acetonitrile;28363-25-9

Chemical Property of 2-[(2-Hydroxyphenyl)amino]acetonitrile

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NCC#N)O

Technology Process of 2-[(2-Hydroxyphenyl)amino]acetonitrile

There total 1 articles about 2-[(2-Hydroxyphenyl)amino]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + potassium cyanide (151-50-8) + 2-amino-phenol (95-55-6) → N-(2-hydroxy-phenyl)-glycine nitrile (28363-25-9)

Guidance literature:

With acetic acid; at 70 - 80 ℃;

DOI:10.1246/bcsj.1.202

Reference yield:

N-(2-hydroxy-phenyl)-glycine nitrile (28363-25-9) → N-acetyl-N-(2-hydroxy-phenyl)-glycine (103205-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: alkali

2: diluted NaOH-solution

With sodium hydroxide;

Reference yield:

N-(2-hydroxy-phenyl)-glycine nitrile (28363-25-9) + acetic anhydride (108-24-7) → N-acetyl-N-(2-hydroxy-phenyl)-glycine nitrile

Guidance literature:

With alkali;

upstream raw materials:

formaldehyd

potassium cyanide

2-amino-phenol

Downstream raw materials:

N-acetyl-N-(2-hydroxy-phenyl)-glycine

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