2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

Base Information

• Chemical Name: 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol
• CAS No.: 146796-49-8
• Molecular Formula: C₁₇H₁₈Cl₂N₄O₂S
• Molecular Weight: 413.328
• Mol file: 146796-49-8.mol

Synonyms:

Chemical Property of 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

There total 4 articles about 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethyl-1,2-oxazole (300-87-8) → 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol (146796-49-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen chloride, 35percent aq. hydrochloric acid / 65 - 70 °C

2: 42 percent / thionyl chloride / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 96 percent / 2 M aq. sodium trithiocarbonate / methanol / 1 h / 0 °C

4: 1.) sodium hydride / 1.) DMF, RT, 30 min., 2.) DMF, RT, 48 h

With hydrogenchloride; thionyl chloride; sodium trithiocarbonate; sodium hydride; In methanol; dichloromethane;

DOI:10.1002/jhet.5570290631

Reference yield:

4-chloromethyl-3,5-dimethylisoxazole (19788-37-5) → 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol (146796-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 2 M aq. sodium trithiocarbonate / methanol / 1 h / 0 °C

2: 1.) sodium hydride / 1.) DMF, RT, 30 min., 2.) DMF, RT, 48 h

With sodium trithiocarbonate; sodium hydride; In methanol;

DOI:10.1002/jhet.5570290631

Reference yield:

4-hydroxymethyl-3,5-dimethylisoxazole (19788-36-4) → 2-(2,4-dichlorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol (146796-49-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / thionyl chloride / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 96 percent / 2 M aq. sodium trithiocarbonate / methanol / 1 h / 0 °C

3: 1.) sodium hydride / 1.) DMF, RT, 30 min., 2.) DMF, RT, 48 h

With thionyl chloride; sodium trithiocarbonate; sodium hydride; In methanol; dichloromethane;

DOI:10.1002/jhet.5570290631

upstream raw materials:

1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane

(3,5-dimethylisoxazol-4-yl)methanethiol

3,5-dimethyl-1,2-oxazole

4-chloromethyl-3,5-dimethylisoxazole