Technology Process of pinacol chloro-5-phenoxypentane-1-boronate
There total 2 articles about pinacol chloro-5-phenoxypentane-1-boronate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
dropwise addn. of an equimolar amt. of the Grignard reagent in THF to a soln. of the boronate in THF at -75°C with stirring; the mixture was allowed to reach room temp. for 1 h and was kept at 20-25°C overnight; performed under Ar;; concn. under vac.; the residue was dissolved in ether; filtration; evapn.;;
DOI:10.1016/0022-328X(92)83330-K
- Guidance literature:
-
In
tetrahydrofuran;
dropwise addn. of an equimolar amt. of the Grignard reagent in THF to a soln. of the boronate in THF at -75°C with stirring; the mixture was allowed to reach room temp. for 1 h and was kept at 20-25°C overnight; performed under Ar;; concn. under vac.; the residue was dissolved in ether; filtration; evapn.;;
DOI:10.1016/0022-328X(92)83330-K
- Guidance literature:
-
With
n-butyllithium; acetic anhydride; acetic acid;
In
tetrahydrofuran; hexane;
Ar atm.; silazane in THF was treated with n-BuLi/hexane at 0°C; cooling to -70°C and addn. of the boronate; warming to room temp. and stirring for 5 h; cooling to -70°C; addn. of (CH3CO)2O and CH3COOH; at 20-25°C overnight;; concn. under vacuum; drying of residue at 80°C under 0.02 torr for 1 h; extn. with hexane (extract was discarded); the residue was dissolved in ether; filtration; crystn. from ether/hexane; elem. anal.;;
DOI:10.1016/0022-328X(92)83330-K
