3-Flavanol, trans-(+)-

Base Information

Chemical Name:3-Flavanol, trans-(+)-
CAS No.:184713-81-3
Molecular Formula:C₁₅H₁₄O₂
Molecular Weight:226.275
Hs Code.:
UNII:V4O52XH7Q5
Nikkaji Number:J1.909.875C
Wikidata:Q27291528
ChEMBL ID:CHEMBL1893898

Synonyms:3-Flavanol, trans-(+)-;V4O52XH7Q5;184713-81-3;2-phenyl-3-chromanol;(2S,3R)-2-phenyl-3,4-dihydro-2H-chromen-3-ol;(+)-(2S,3R)-trans-3-Hydroxyflavan;UNII-V4O52XH7Q5;2H-1-Benzopyran-3-ol, 3,4-dihydro-2-phenyl-, (2S,3R)-;2H-1-Benzopyran-3-ol, 3,4-dihydro-2-phenyl-, (2S-trans)-;trans 3-flavanol;trans-(+)-3-flavanol;(2S,3R)-Flavan-3-ol;MLS001178742;SCHEMBL1659938;CHEMBL1893898;CHEBI:182419;OEIJRRGCTVHYTH-HIFRSBDPSA-N;SMR000477467;C21379;AO-079/15259065;2beta-Phenyl-3,4-dihydro-2H-1-benzopyran-3alpha-ol;Q27291528

Suppliers and Price of 3-Flavanol, trans-(+)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-Flavanol, trans-(+)-

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:226.099379685
Heavy Atom Count:17
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C(OC2=CC=CC=C21)C3=CC=CC=C3)O
Isomeric SMILES:C1[C@H]([C@@H](OC2=CC=CC=C21)C3=CC=CC=C3)O

Technology Process of 3-Flavanol, trans-(+)-

There total 11 articles about 3-Flavanol, trans-(+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1350895-99-6
(1R,2R)-3-(2-hydroxyphenyl)-1-phenylpropane-1,2-diol

: 184713-81-3
(2S,3R)-trans-flavan-3-ol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 14h;
DOI:10.1016/j.tet.2014.03.052

Reference yield:

: 1350895-98-5
C₁₇H₂₀O₄

: 55568-98-4
(2R,3S)-2-phenylchroman-3-ol

: 184713-81-3
(2S,3R)-trans-flavan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol; diethyl ether; water / 7.5 h / Reflux

2: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: dichloromethane / 1.17 h / 0 °C / Inert atmosphere; Molecular sieve

4: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere

5: sodium tetrahydroborate / methanol; tert-butyl methyl ether / 1.25 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; pyridinium p-toluenesulfonate; potassium carbonate; In methanol; diethyl ether; dichloromethane; tert-butyl methyl ether; water; acetone;
DOI:10.1016/j.bmcl.2011.09.116

Reference yield:

: 4187-87-5
1-Phenyl-2-propyn-1-ol

: 55568-98-4
(2R,3S)-2-phenylchroman-3-ol

: 184713-81-3
(2S,3R)-trans-flavan-3-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere

3.1: toluene / 31 h / 110 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: AD-mix β; methanesulfonamide / tetrahydrofuran; water; tert-butyl alcohol / 120 h / 0 °C

6.1: hydrogenchloride / methanol; diethyl ether; water / 7.5 h / Reflux

7.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: dichloromethane / 1.17 h / 0 °C / Inert atmosphere; Molecular sieve

9.1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere

10.1: sodium tetrahydroborate / methanol; tert-butyl methyl ether / 1.25 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; methanesulfonamide; di-isopropyl azodicarboxylate; AD-mix β; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; tert-butyl methyl ether; water; acetone; toluene; tert-butyl alcohol; 1.1: Mitsunobu reaction / 5.1: Sharpless dihydroxylation;
DOI:10.1016/j.bmcl.2011.09.116