Technology Process of C16H15F2NO3
There total 6 articles about C16H15F2NO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - -20 ℃;
Inert atmosphere;
DOI:10.1021/jm301113w
- Guidance literature:
-
Multi-step reaction with 7 steps
1: aluminum (III) chloride / 1,2-dichloro-ethane / 4 °C
2: zinc / acetic acid / 70 °C
3: potassium hydroxide / acetonitrile / 2 h / 80 °C
4: sodium hydroxide; water / methanol / 70 °C
5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h / 0 - 20 °C
6: dichloromethane; ethanol / 24 h / 0 - 20 °C
7: boron tribromide / dichloromethane / -78 - -20 °C / Inert atmosphere
With
aluminum (III) chloride; oxalyl dichloride; water; boron tribromide; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; zinc;
In
methanol; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm301113w
- Guidance literature:
-
Multi-step reaction with 6 steps
1: zinc / acetic acid / 70 °C
2: potassium hydroxide / acetonitrile / 2 h / 80 °C
3: sodium hydroxide; water / methanol / 70 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h / 0 - 20 °C
5: dichloromethane; ethanol / 24 h / 0 - 20 °C
6: boron tribromide / dichloromethane / -78 - -20 °C / Inert atmosphere
With
oxalyl dichloride; water; boron tribromide; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; zinc;
In
methanol; ethanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/jm301113w
