5-BETA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3-ACETATE

Base Information

Chemical Name:5-BETA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3-ACETATE
CAS No.:36623-16-2
Molecular Formula:C₂₃H₃₄O₆
Molecular Weight:406.519
Hs Code.:
Mol file:36623-16-2.mol

Synonyms:

Suppliers and Price of 5-BETA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3-ACETATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3α,5β-TetrahydroCortisone3-Acetate
5mg
$ 345.00

TRC
3α,5β-TetrahydroCortisone3-Acetate
1mg
$ 75.00

American Custom Chemicals Corporation
5-BETA-PREGNAN-3-ALPHA,17,21-TRIOL-11,20-DIONE 3-ACETATE 95.00%
5MG
$ 502.89

Total 5 raw suppliers

Chemical Property of 5-BETA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3-ACETATE

Chemical Property:

Boiling Point:547.5±50.0 °C(Predicted)
PKA:12.36±0.70(Predicted)
Density:1.24±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

3α,5β-TetrahydroCortisone3-Acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses In order to develop specific and sensitive immunoassays, carboxylated derivatives of tetrahydrocortisol and tetrahydrocortisone were synthesized using 3α,5β-Tetrahydro Cortisone 3-Acetate and others.

Technology Process of 5-BETA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3-ACETATE

There total 10 articles about 5-BETA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3-ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-03-3
hydrocortisone acetate

: 36623-16-2
tetrahydrocortisone 3-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 7.4 g / H₂ / palladium on calcium carbonate / pyridine / 12 h

2: saponification

3: 2.2 g / imidazole / pyridine; dimethylformamide / 1 h / Ambient temperature

4: 410 mg / H₂ / Raney nickel (W-2) / dioxane / 10 h

5: 500 mg / pyridine / 12 h / Ambient temperature

6: 440 mg / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

7: 300 mg / 30 percent H₂SO₄ / acetone / 0.5 h / Ambient temperature

With 1H-imidazole; sulfuric acid; hydrogen; pyridinium chlorochromate; palladium on activated charcoal; Raney nickel (W-2); In 1,4-dioxane; pyridine; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.30.2110

Reference yield:

: 1482-50-4,71973-95-0
5β-pregnane-11β,17α,21-triol-3,20-dione

: 36623-16-2
tetrahydrocortisone 3-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 2.2 g / imidazole / pyridine; dimethylformamide / 1 h / Ambient temperature

2: 410 mg / H₂ / Raney nickel (W-2) / dioxane / 10 h

3: 500 mg / pyridine / 12 h / Ambient temperature

4: 440 mg / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

5: 300 mg / 30 percent H₂SO₄ / acetone / 0.5 h / Ambient temperature

With 1H-imidazole; sulfuric acid; hydrogen; pyridinium chlorochromate; Raney nickel (W-2); In 1,4-dioxane; pyridine; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.30.2110

Reference yield:

: 64313-94-6
RU 18760

: 36623-16-2
tetrahydrocortisone 3-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: saponification

2: 2.2 g / imidazole / pyridine; dimethylformamide / 1 h / Ambient temperature

3: 410 mg / H₂ / Raney nickel (W-2) / dioxane / 10 h

4: 500 mg / pyridine / 12 h / Ambient temperature

5: 440 mg / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

6: 300 mg / 30 percent H₂SO₄ / acetone / 0.5 h / Ambient temperature

With 1H-imidazole; sulfuric acid; hydrogen; pyridinium chlorochromate; Raney nickel (W-2); In 1,4-dioxane; pyridine; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.30.2110