methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal

Base Information

• Chemical Name: methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal
• CAS No.: 75626-70-9
• Molecular Formula: C₃₀H₃₄N₂O₈
• Molecular Weight: 550.609
• Mol file: 75626-70-9.mol

Synonyms:

Chemical Property of methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal

There total 8 articles about methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-(N-benzyloxycarbonylamino)tetrahydrofuran-2-one (31332-88-4) → methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal (75626-70-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH / dioxane

3: pyridine, chromium trioxide / CH₂Cl₂

4: 1.) acetic acid, 2.) sodium cyanoborohydride / 1.) ethanol, 15 min, 2.) 30 min

With pyridine; chromium(VI) oxide; sodium hydroxide; sodium cyanoborohydride; acetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jo00314a029

Reference yield:

benzyl DL-N-(benzyloxycarbonyl)homoserinate (58611-62-4) → methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal (75626-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, chromium trioxide / CH₂Cl₂

2: 1.) acetic acid, 2.) sodium cyanoborohydride / 1.) ethanol, 15 min, 2.) 30 min

With pyridine; chromium(VI) oxide; sodium cyanoborohydride; acetic acid; In dichloromethane;

DOI:10.1021/jo00314a029

Reference yield:

sodium 2-<<(benzyloxy)carbonyl>amino>-4-hydroxybutanoate (75626-75-4) → methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal (75626-70-9)

Guidance literature:

Multi-step reaction with 3 steps

2: pyridine, chromium trioxide / CH₂Cl₂

3: 1.) acetic acid, 2.) sodium cyanoborohydride / 1.) ethanol, 15 min, 2.) 30 min

With pyridine; chromium(VI) oxide; sodium cyanoborohydride; acetic acid; In dichloromethane;

DOI:10.1021/jo00314a029

upstream raw materials:

2-BENZYLOXYCARBONYLAMINO-4-OXO-BUTYRIC ACID BENZYL ESTER

methyl 4-amino-α-oxophenylacetate dimethyl ketal

(S)-3-(N-benzyloxycarbonylamino)tetrahydrofuran-2-one

benzyl DL-N-(benzyloxycarbonyl)homoserinate